Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 1/20 | 0.57 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.57 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.57 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.57 |
| ▸ | MKNK1 | Q9BUB5 | 4/20 | 0.54 |
| ▸ | MKNK2 | Q9HBH9 | 4/20 | 0.54 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | KIF11 | P52732 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.44 |
| ▸ | DEGS1 | O15121 | 1/20 | 0.44 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.43 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | NAMPT | P43490 | 1/20 | 0.43 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2345607 | 0.85 | CYP19A1 (0.74) | CYP19A1CYP11B1CYP11B2SLC2A1MKNK1 | |
| SCHEMBL3000715 | 0.81 | ALOX5AP (0.57) | CYP19A1CYP11B1CYP11B2MKNK1MKNK2 | |
| SCHEMBL14082483 | 0.76 | MKNK1 (0.70) | CYP19A1CYP11B1CYP11B2MKNK1MKNK2 | |
| SCHEMBL2253360 | 0.76 | CA1 (0.65) | LMNAALDH1A1GAA | |
| SCHEMBL13188366 | 0.75 | CYP11B1 (0.67) | CYP19A1CYP11B1CYP11B2SLC2A1MKNK1 | |
| SCHEMBL14527404 | 0.74 | KIF11 (0.71) | MKNK1MKNK2LMNAKIF11SMN1; SMN2 | |
| SCHEMBL12251075 | 0.73 | MKNK1 (0.70) | CYP19A1CYP11B1CYP11B2MKNK1MKNK2 | |
| SCHEMBL10168702 | 0.73 | CYP19A1 (0.64) | CYP19A1CYP11B1CYP11B2SLC2A1MKNK1 | |
| SCHEMBL10028698 | 0.73 | CYP19A1 (0.68) | CYP19A1CYP11B1CYP11B2SLC2A1MKNK1 | |
| SCHEMBL3511516 | 0.73 | CYP19A1 (0.68) | CYP19A1CYP11B1CYP11B2SLC2A1MKNK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2546232-A1 | Diphenyl Substituted Alkanes | Merck Sharp & Dohme Corp. (US) | 2013-01-16 | — | — | EP | disclosed |
| US-20100190761-A1 | DIPHENYL SUBSTITUTED ALKANES | MERCK SHARP & DOHME CORP. | 2010-07-29 | — | — | US | disclosed |
| EP-2170065-A1 | DIPHENYL SUBSTITUTED ALKANES | Merck Sharp & Dohme Corp. (US) | 2010-04-07 | — | — | EP | disclosed |
| WO-2008156721-A1 | DIPHENYL SUBSTITUTED ALKANES | MERCK & CO., INC. (US) | 2008-12-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100190761-A1 | DIPHENYL SUBSTITUTED ALKANES | ALOX5, ALOX15, ALOX15B | CYP19A1 835/4885CYP11B1 237/4885CYP11B2 290/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.