Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | EGFR | P00533 | 1/20 | 0.32 |
| ▸ | CA1 | P00915 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | FYN | P06241 | 1/20 | 0.32 |
| ▸ | MMP2 | P08253 | 1/20 | 0.32 |
| ▸ | MMP9 | P14780 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | MMP8 | P22894 | 1/20 | 0.32 |
| ▸ | CA6 | P23280 | 1/20 | 0.32 |
| ▸ | CDK2 | P24941 | 1/20 | 0.32 |
| ▸ | MMP12 | P39900 | 1/20 | 0.32 |
| ▸ | RECQL | P46063 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.32 |
| ▸ | AKT1 | P31749 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1980294 | 1.00 | ADAMTS4 (0.32) | ADAMTS4ALDH1A1EGFRCA1CA2 | |
| SCHEMBL9904685 | 0.82 | ITGB2 (0.38) | ADAMTS4ALDH1A1EGFRCA1CA2 | |
| SCHEMBL21262971 | 0.79 | ALDH1A1 (0.35) | ADAMTS4ALDH1A1EGFRCA1CA2 | |
| SCHEMBL1764717 | 0.76 | CNR1 (0.34) | ADAMTS4ALDH1A1EGFRCA1CA2 | |
| SCHEMBL21116508 | 0.72 | HTR1A (0.39) | ALDH1A1CA1CA2HSD17B10TDP1 | |
| SCHEMBL31304774 | 0.70 | PLK1 (0.41) | — | |
| SCHEMBL18199055 | 0.69 | TMEM97 (0.32) | — | |
| SCHEMBL16661511 | 0.69 | ITGB2 (0.37) | LMNAAKT1ITGB2ICAM1ITGAL | |
| SCHEMBL9904847 | 0.69 | BCL2L1 (0.33) | ADAMTS4ALDH1A1EGFRCA1CA2 | |
| SCHEMBL18025155 | 0.68 | TSHR (0.36) | CA1CA2LMNAALOX15HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250304564-A1 | NOVEL KV3 MODULATORS | AUTIFONY THERAPEUTICS LTD (GB) | 2025-10-02 | — | — | US | disclosed |
| US-12358901-B2 | KV3 modulators | AUTIFONY THERAPEUTICS LIMITED (GB) | 2025-07-15 | — | — | US | disclosed |
| CN-115066424-B | Kv3 modulators | 奥蒂福尼疗法有限公司 | 2024-12-27 | — | — | CN | disclosed |
| CN-117751119-A | Potassium channel modulators | 奥蒂福尼疗法有限公司 | 2024-03-22 | — | — | CN | disclosed |
| WO-2023017263-A1 | POTASSIUM CHANNEL MODULATORS | AUTIFONY THERAPEUTICS LIMITED (GB) | 2023-02-16 | — | — | WO | disclosed |
| CN-115380032-A | KV3 enhancers for the treatment of cognitive disorders | 豪夫迈·罗氏有限公司 | 2022-11-22 | — | — | CN | disclosed |
| CN-115066424-A | Kv3 modulators | 奥蒂福尼疗法有限公司 | 2022-09-16 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12358901-B2 | KV3 modulators | KCNN3, KCNA3, KCNH3 | ADAMTS4 4561/4885ALDH1A1 3109/4885EGFR 3926/4885 |
| US-20250304564-A1 | NOVEL KV3 MODULATORS | KCNN3, KCNA3, KCND3 | ADAMTS4 4501/4885ALDH1A1 3250/4885EGFR 4159/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.