Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | MTNR1A | P48039 | 3/20 | 0.36 |
| ▸ | MTNR1B | P49286 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | LOXL2 | Q9Y4K0 | 2/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.35 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.35 |
| ▸ | KIF11 | P52732 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13248558 | 0.82 | MTNR1A (0.52) | L3MBTL1KDM4EMTNR1AMTNR1BNPC1 | |
| SCHEMBL2993524 | 0.82 | HTR6 (0.40) | HTR6L3MBTL1HDAC1HDAC6KDM4E | |
| SCHEMBL20337590 | 0.81 | KMT2A (0.43) | HTR6L3MBTL1KDM4EMEN1KMT2A | |
| SCHEMBL25272713 | 0.80 | HTR6 (0.43) | HTR6L3MBTL1KDM4EMEN1KMT2A | |
| SCHEMBL9904372 | 0.80 | HTR6 (0.43) | HTR6L3MBTL1HDAC1HDAC6KDM4E | |
| SCHEMBL17442691 | 0.80 | HTR6 (0.43) | HTR6L3MBTL1HDAC1HDAC6KDM4E | |
| SCHEMBL4517096 | 0.80 | L3MBTL1 (0.58) | HTR6L3MBTL1MEN1KMT2AEPHX1 | |
| SCHEMBL14439422 | 0.79 | HTR6 (0.42) | HTR6L3MBTL1HDAC1HDAC6KDM4E | |
| SCHEMBL2999358 | 0.77 | HTR6 (0.48) | HTR6L3MBTL1HDAC1HDAC6KDM4E | |
| SCHEMBL143209 | 0.73 | RAB9A (0.39) | HTR6L3MBTL1HDAC1HDAC6KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9340548-B2 | Substituted pyrazolo[3,4-a]carbazoles as hepatitis C inhibitors | Boehringer Ingehleim International GmbH (DE) | 2016-05-17 | — | — | US | disclosed |
| US-9340548-B2 | Substituted pyrazolo[3,4-a]carbazoles as hepatitis C inhibitors | Boehringer Ingehleim International GmbH (DE) | 2016-05-17 | — | — | US | disclosed |
| US-20150291592-A1 | HEPATITIS C INHIBITOR COMPOUNDS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2015-10-15 | — | — | US | disclosed |
| US-20150291592-A1 | HEPATITIS C INHIBITOR COMPOUNDS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2015-10-15 | — | — | US | disclosed |
| WO-2013026162-A1 | HEPATITIS C INHIBITOR COMPOUNDS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2013-02-28 | — | — | WO | disclosed |
| US-20100190773-A1 | Anti-Cytokine Heterocyclic Compounds | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-07-29 | — | — | US | disclosed |
| US-20100190773-A1 | Anti-Cytokine Heterocyclic Compounds | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-07-29 | — | — | US | disclosed |
| US-20060276496-A1 | Anti-Cytokine Heterocyclic Compounds | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2006-12-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060276496-A1 | Anti-Cytokine Heterocyclic Compounds | MAPKAPK2, MAP4K2, MAP3K2 | HTR6 4219/4885L3MBTL1 3819/4885HDAC1 494/4885 |
| US-20100190773-A1 | Anti-Cytokine Heterocyclic Compounds | MAPKAPK2, MAP4K2, MAP3K2 | HTR6 4219/4885L3MBTL1 3819/4885HDAC1 494/4885 |
| US-20150291592-A1 | HEPATITIS C INHIBITOR COMPOUNDS | HAVCR2, CD4, HAX1 | HTR6 3755/4885L3MBTL1 2238/4885HDAC1 1488/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.