Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 2/20 | 0.43 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.39 |
| ▸ | GRM7 | Q14831 | 1/20 | 0.38 |
| ▸ | NR3C1 | P04150 | 3/20 | 0.38 |
| ▸ | NR3C2 | P08235 | 3/20 | 0.38 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.37 |
| ▸ | DRD3 | P35462 | 1/20 | 0.37 |
| ▸ | KCNE1 | P15382 | 3/20 | 0.36 |
| ▸ | KCNQ1 | P51787 | 3/20 | 0.36 |
| ▸ | LTB4R | Q15722 | 2/20 | 0.36 |
| ▸ | LTB4R2 | Q9NPC1 | 2/20 | 0.36 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.33 |
| ▸ | JAK2 | O60674 | 2/20 | 0.33 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.33 |
| ▸ | JAK1 | P23458 | 2/20 | 0.33 |
| ▸ | JAK3 | P52333 | 2/20 | 0.33 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.33 |
| ▸ | ROS1 | P08922 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29920642 | 1.00 | CA2 (0.43) | CA2HCRTR2GRM7NR3C1NR3C2 | |
| SCHEMBL29920659 | 0.84 | CA2 (0.32) | CA2NR3C1NR3C2LTB4RLTB4R2 | |
| SCHEMBL29920587 | 0.84 | CA2 (0.32) | CA2NR3C1NR3C2LTB4RLTB4R2 | |
| SCHEMBL29920510 | 0.84 | CA2 (0.32) | CA2NR3C1NR3C2LTB4RLTB4R2 | |
| SCHEMBL29920570 | 0.81 | CA2 (0.42) | CA2HCRTR2DRD2DRD3LTB4R | |
| SCHEMBL29920552 | 0.81 | CA2 (0.42) | CA2HCRTR2DRD2DRD3LTB4R | |
| SCHEMBL29920403 | 0.76 | LTB4R (0.44) | CA2NR3C1NR3C2LTB4RLTB4R2 | |
| SCHEMBL29920554 | 0.76 | LTB4R (0.44) | CA2NR3C1NR3C2LTB4RLTB4R2 | |
| SCHEMBL29920414 | 0.68 | HCRTR2 (0.37) | CA2HCRTR2AKR1B1DRD2DRD3 | |
| SCHEMBL31040776 | 0.67 | DRD2 (0.43) | CA2HCRTR2GRM7DRD2DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022217248-A1 | SUBSTITUTED SULFONAMIDE-CHROMAN COMPOUNDS, AND PHARMACEUTICAL COMPOSITIONS, AND METHODS OF USE THEREOF | SUNOVION PHARMACEUTICALS INC. (US) | 2022-10-13 | — | — | WO | disclosed |