SCHEMBL29924031

SCHEMBL29924031

COc1ccc(-c2cccc(C)c2C)c(OC)c1-c1ccccc1Br

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
RAB9A P51151 4/20 0.39
SMN1; SMN2 Q16637 3/20 0.39
NPC1 O15118 2/20 0.39
ALDH1A1 P00352 6/20 0.38
MAPT P10636 5/20 0.38
MEN1 O00255 3/20 0.38
KMT2A Q03164 3/20 0.38
KDM4E B2RXH2 2/20 0.38
USP2 O75604 1/20 0.38
DUSP3 P51452 1/20 0.38
TDP1 Q9NUW8 1/20 0.38
MAOA P21397 1/20 0.37
MAOB P27338 1/20 0.37
HDAC4 P56524 1/20 0.37
HDAC2 Q92769 1/20 0.37
HDAC8 Q9BY41 1/20 0.37
ELANE P08246 1/20 0.35
ADORA2A P29274 2/20 0.34
ADORA3 P0DMS8 1/20 0.34
RXFP1 Q9HBX9 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29924277 0.84 MAOA (0.42) RAB9ASMN1; SMN2NPC1ALDH1A1MAPT
SCHEMBL29924021 0.80 MAOA (0.35) ALDH1A1MAOAMAOB
SCHEMBL10177310 0.79 ALDH1A1 (0.43) RAB9ASMN1; SMN2NPC1ALDH1A1MAPT
SCHEMBL29924095 0.78 RAB9A (0.35) RAB9ASMN1; SMN2NPC1ALDH1A1MAPT
SCHEMBL5460185 0.76 KDM4E (0.44) RAB9ASMN1; SMN2NPC1ALDH1A1MAPT
SCHEMBL366191 0.75 TOP1 (0.48) RAB9ASMN1; SMN2ALDH1A1MAPTMEN1
SCHEMBL1768355 0.73 TOP1 (0.47) RAB9ASMN1; SMN2ALDH1A1MAPTMEN1
SCHEMBL28888561 0.73 TOP1 (0.41) RAB9ASMN1; SMN2ALDH1A1MAPTMEN1
SCHEMBL28888551 0.73 ALDH1A1 (0.52) RAB9ASMN1; SMN2NPC1ALDH1A1MAOA
SCHEMBL5459904 0.72 NPC1 (0.44) RAB9ASMN1; SMN2NPC1ALDH1A1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115181128-A Phosphine ligand of arylmethyl biaryl and transition metal complex thereof 东莞市均成高新材料有限公司 2022-10-14 CN disclosed