Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 10/20 | 0.57 |
| ▸ | RAB9A | P51151 | 10/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.57 |
| ▸ | EEF2K | O00418 | 2/20 | 0.57 |
| ▸ | POLB | P06746 | 2/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 8/20 | 0.55 |
| ▸ | MAPT | P10636 | 6/20 | 0.55 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.47 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.47 |
| ▸ | RELA | Q04206 | 1/20 | 0.47 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4705999 | 0.86 | ALDH1A1 (0.51) | NPC1RAB9AKDM4EALDH1A1EEF2K | |
| SCHEMBL22699230 | 0.84 | NPC1 (0.47) | NPC1RAB9AKDM4EALDH1A1EEF2K | |
| SCHEMBL22699072 | 0.81 | NPC1 (0.44) | NPC1RAB9AKDM4EALDH1A1EEF2K | |
| SCHEMBL13154846 | 0.80 | MAPT (0.40) | NPC1RAB9AKDM4EALDH1A1EEF2K | |
| SCHEMBL22699224 | 0.79 | KDM4E (0.45) | NPC1RAB9AKDM4EALDH1A1EEF2K | |
| SCHEMBL4705577 | 0.77 | RAB9A (0.38) | NPC1RAB9AKDM4EALDH1A1EEF2K | |
| SCHEMBL22699269 | 0.76 | ALDH1A1 (0.41) | NPC1RAB9AKDM4EALDH1A1EEF2K | |
| SCHEMBL4702022 | 0.76 | MAPT (0.40) | NPC1RAB9AKDM4EALDH1A1EEF2K | |
| SCHEMBL29926093 | 0.76 | NPC1 (0.54) | NPC1RAB9AKDM4EALDH1A1EEF2K | |
| SCHEMBL22699195 | 0.74 | ALDH1A1 (0.48) | NPC1RAB9AKDM4EALDH1A1EEF2K |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220273669-A1 | NATRIURETIC PEPTIDE RECEPTOR A AGONISTS USEFUL FOR THE TREATMENT OF CARDIOMETABOLIC DISEASES, KIDNEY DISEASE AND DIABETES | MERCK SHARP DOHME CORP. (US) | 2022-09-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220273669-A1 | NATRIURETIC PEPTIDE RECEPTOR A AGONISTS USEFUL FOR THE TREATMENT OF CARDIOMETABOLIC DISEASES, KIDNEY DISEASE AND DIABETES | NPR1, NPPA, NPR3 | NPC1 153/4885RAB9A 2564/4885KDM4E 3469/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.