Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | TOP1 | P11387 | 2/20 | 0.31 |
| ▸ | ELANE | P08246 | 1/20 | 0.31 |
| ▸ | CD69 | Q07108 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 2/20 | 0.31 |
| ▸ | HTT | P42858 | 2/20 | 0.31 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.31 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.31 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | THRB | P10828 | 1/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2990792 | 1.00 | POLB (0.34) | POLBMEN1KMT2AHDAC1MAPT | |
| SCHEMBL2986985 | 0.79 | PTPRB (0.44) | POLBMEN1KMT2ACD69ACHE | |
| SCHEMBL2990563 | 0.79 | PTPRB (0.44) | POLBMEN1KMT2ACD69ACHE | |
| SCHEMBL12012728 | 0.77 | HTT (0.36) | POLBMEN1KMT2AMAPTLMNA | |
| SCHEMBL6067643 | 0.76 | GSTA1 (0.44) | — | |
| SCHEMBL12012734 | 0.71 | LMNA (0.48) | POLBMEN1KMT2AMAPTELANE | |
| SCHEMBL9276839 | 0.71 | LMNA (0.42) | POLBMAPTTOP1ELANECD69 | |
| SCHEMBL2984853 | 0.70 | CFD (0.38) | POLBMAPTTOP1ELANECD69 | |
| SCHEMBL11873114 | 0.67 | CYP2C9 (0.41) | POLBMEN1KMT2AHDAC1MAPT | |
| SCHEMBL2534198 | 0.65 | TSHR (0.40) | POLBMEN1KMT2ATP53GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8252954-B2 | Processes for the preparation of calixarene derivatives | THE CURATORS OF THE UNIVERSITY OF MISSOURI (US) | 2012-08-28 | — | — | US | disclosed |
| US-20100185022-A1 | PROCESSES FOR THE PREPARATION OF CALIXARENE DERIVATIVES | THE UNIVERSITY OF WESTERN AUSTRALIA (AU) | 2010-07-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100185022-A1 | PROCESSES FOR THE PREPARATION OF CALIXARENE DERIVATIVES | CALD1, CANX, CALU | POLB 1227/4885MEN1 4093/4885KMT2A 4773/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.