Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AXL | P30530 | 2/20 | 0.40 |
| ▸ | L3MBTL3 | Q96JM7 | 2/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 8/20 | 0.35 |
| ▸ | CSF1R | P07333 | 1/20 | 0.34 |
| ▸ | CDK4 | P11802 | 1/20 | 0.34 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | MBTD1 | Q05BQ5 | 1/20 | 0.33 |
| ▸ | EGFR | P00533 | 1/20 | 0.33 |
| ▸ | TOP1 | P11387 | 1/20 | 0.33 |
| ▸ | TOP2A | P11388 | 1/20 | 0.33 |
| ▸ | NPY2R | P49146 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.32 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29928123 | 0.99 | AXL (0.39) | AXLL3MBTL3L3MBTL1HRH3CSF1R | |
| SCHEMBL30299345 | 0.97 | AXL (0.38) | AXLL3MBTL3L3MBTL1HRH3CSF1R | |
| SCHEMBL30299369 | 0.92 | AXL (0.37) | AXLHRH3ALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL30090654 | 0.91 | PDE3B (0.34) | AXLHRH3ALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL30090486 | 0.91 | KCNH2 (0.39) | AXLL3MBTL1CDK4ALDH1A1EGFR | |
| SCHEMBL30299368 | 0.91 | GAA (0.38) | AXLALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL30090687 | 0.91 | AXL (0.38) | AXLALDH1A1LMNA | |
| SCHEMBL30299298 | 0.90 | ALDH1A1 (0.32) | AXLHRH3ALDH1A1SMN1; SMN2 | |
| SCHEMBL30299388 | 0.89 | ROCK2 (0.34) | AXLHRH3CSF1RCDK4CDK6 | |
| SCHEMBL30299325 | 0.89 | ROCK2 (0.32) | AXLHRH3CSF1RCDK4CDK6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115916344-A | AXL inhibitors for antiviral therapy | 卑尔根生物股份公司 | 2023-04-04 | — | — | CN | claimed |
| CN-116075303-A | Method of selecting patients treated with a combination of an AXL inhibitor and an immune checkpoint modulator | 卑尔根生物股份公司 | 2023-05-05 | — | — | CN | disclosed |
| CN-115916344-A | AXL inhibitors for antiviral therapy | 卑尔根生物股份公司 | 2023-04-04 | — | — | CN | disclosed |
| CN-115414480-A | Dianhydrogalactitol in combination with radiation for treatment of non-small cell lung cancer and glioblastoma multiforme | 德玛医药 | 2022-12-02 | — | — | CN | disclosed |
| CN-110551105-B | Substituted triazoles useful as AXL inhibitors | 里格尔制药公司 | 2022-10-18 | — | — | CN | disclosed |