Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AXL | P30530 | 3/20 | 0.37 |
| ▸ | INSR | P06213 | 1/20 | 0.37 |
| ▸ | KDR | P35968 | 1/20 | 0.37 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | GFER | P55789 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | GLA | P06280 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | PARP1 | P09874 | 2/20 | 0.32 |
| ▸ | PARP2 | Q9UGN5 | 2/20 | 0.32 |
| ▸ | HTR1A | P08908 | 2/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.32 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30090687 | 0.99 | AXL (0.38) | AXLINSRKDRABCB1ALDH1A1 | |
| SCHEMBL29929683 | 0.92 | AXL (0.40) | AXLALDH1A1LMNASMN1; SMN2HRH3 | |
| SCHEMBL30299345 | 0.91 | AXL (0.38) | AXLINSRKDRALDH1A1LMNA | |
| SCHEMBL29928123 | 0.91 | AXL (0.39) | AXLALDH1A1SMN1; SMN2HRH3 | |
| SCHEMBL30090486 | 0.89 | KCNH2 (0.39) | AXLKDRALDH1A1HTR1AALK | |
| SCHEMBL30299325 | 0.89 | ROCK2 (0.32) | AXLALDH1A1KDM4ESMN1; SMN2HRH3 | |
| SCHEMBL30299388 | 0.87 | ROCK2 (0.34) | AXLALDH1A1KMT2AKDM4ESMN1; SMN2 | |
| SCHEMBL30299368 | 0.87 | GAA (0.38) | AXLALDH1A1LMNAMAPTMAPK1 | |
| SCHEMBL30090654 | 0.87 | PDE3B (0.34) | AXLALDH1A1LMNAMAPK1SMN1; SMN2 | |
| SCHEMBL30299298 | 0.86 | ALDH1A1 (0.32) | AXLALDH1A1SMN1; SMN2HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116075303-A | Method of selecting patients treated with a combination of an AXL inhibitor and an immune checkpoint modulator | 卑尔根生物股份公司 | 2023-05-05 | — | — | CN | disclosed |
| CN-115916344-A | AXL inhibitors for antiviral therapy | 卑尔根生物股份公司 | 2023-04-04 | — | — | CN | disclosed |