Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 1/20 | 0.35 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.35 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.35 |
| ▸ | DDB1 | Q16531 | 4/20 | 0.33 |
| ▸ | CRBN | Q96SW2 | 4/20 | 0.33 |
| ▸ | SPR | P35270 | 1/20 | 0.33 |
| ▸ | F13A1 | P00488 | 1/20 | 0.32 |
| ▸ | TGM2 | P21980 | 1/20 | 0.32 |
| ▸ | TGM1 | P22735 | 1/20 | 0.32 |
| ▸ | KCNK3 | O14649 | 4/20 | 0.32 |
| ▸ | KCNK9 | Q9NPC2 | 4/20 | 0.32 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.31 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.31 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.31 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.31 |
| ▸ | KDR | P35968 | 1/20 | 0.31 |
| ▸ | LTA4H | P09960 | 2/20 | 0.31 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.31 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29930870 | 1.00 | PARP1 (0.35) | PARP1HSD11B1GPR119DDB1CRBN | |
| SCHEMBL27031246 | 0.88 | PDCD1 (0.33) | DDB1CRBNSPRLTA4H | |
| SCHEMBL27031096 | 0.88 | PDCD1 (0.33) | DDB1CRBNSPRLTA4H | |
| SCHEMBL31289268 | 0.84 | GPR119 (0.36) | PARP1GPR119DDB1CRBNSPR | |
| SCHEMBL29930722 | 0.84 | TBK1 (0.43) | GPR119DDB1CRBNTBK1 | |
| SCHEMBL27031087 | 0.84 | PIM1 (0.40) | PARP1HSD11B1DDB1CRBN | |
| SCHEMBL29930417 | 0.83 | KCNK3 (0.36) | HSD11B1GPR119DDB1CRBNKCNK3 | |
| SCHEMBL29930574 | 0.82 | IDO1 (0.44) | PARP1GPR119DDB1CRBNTBK1 | |
| SCHEMBL27031245 | 0.82 | IDO1 (0.44) | PARP1GPR119DDB1CRBNTBK1 | |
| SCHEMBL29930847 | 0.81 | DDB1 (0.38) | GPR119DDB1CRBN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250276964-A1 | Benzisoxazole Derivatives and Uses thereof | NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH, INC. | 2025-09-04 | — | — | US | disclosed |
| EP-4308559-A1 | BENZISOXAZOLE DERIVATIVES AND USES THEREOF | Novartis AG (CH) | 2024-01-24 | — | — | EP | disclosed |
| WO-2022195355-A1 | BENZISOXAZOLE DERIVATIVES AND USES THEREOF | NOVARTIS AG (CH) | 2022-09-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250276964-A1 | Benzisoxazole Derivatives and Uses thereof | HBZ, ZFX, WIZ | PARP1 3469/4885HSD11B1 1301/4885GPR119 1427/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.