Phosphoric Acid

Phosphoric Acid

SCHEMBL2993369

C=C(C(=O)O)C(CC(O)CO)CC(O)CO.O=P(O)(O)O

nearest known ligand 0.32

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Known targets — ChEMBL curated mechanism

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

The experimentally established mechanism targets of Phosphoric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
LMNA P02545 2/20 0.31
ALDH1A1 P00352 1/20 0.31
PEPD P12955 1/20 0.30
OR51E2 Q9H255 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4266242 0.94 LMNA (0.35) LMNAALDH1A1OR51E2
SCHEMBL28114949 0.75 OR51E2 (0.37) LMNAALDH1A1OR51E2
Methacrylic Acid SCHEMBL243352 0.75 LMNA (0.39) LMNAALDH1A1PEPDOR51E2
Methacrylic Acid SCHEMBL18043470 0.75 LMNA (0.39) LMNAALDH1A1PEPDOR51E2
Methacrylic Acid SCHEMBL890487 0.75 LMNA (0.39) LMNAALDH1A1PEPDOR51E2
Methacrylic Acid SCHEMBL25371236 0.75 LMNA (0.39) LMNAALDH1A1PEPDOR51E2
Methacrylic Acid SCHEMBL2989895 0.75 LMNA (0.39) LMNAALDH1A1PEPDOR51E2
Phosphoric Acid SCHEMBL890455 0.75 PEPD (0.32) PEPD
SCHEMBL7262226 0.74
SCHEMBL7164603 0.73 TET2 (0.32) LMNAALDH1A1OR51E2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7780449-B2 Hydrophilic endodontic sealing compositions and methods for using such compositions ULTRADENT PRODUCTS, INC. (US) 2010-08-24 US disclosed
US-7320598-B2 Method for filling and sealing a root canal ULTRADENT PRODUCTS, INC. (US) 2008-01-22 US disclosed
US-20050196726-A1 Hydrophilic endodontic sealing compositions and methods for using such compositions ULTRADENT PRODUCTS, INC. 2005-09-08 US disclosed
EP-0981273-A4 ADHESIVE, ANTIMICROBIAL AND/OR REPARATIVE DENTIN STIMULATING DENTAL COMPOSITIONS AND METHODS FOR FORMING AND USING SUCH COMPOSITIONS ULTRADENT PRODUCTS INC (US) 2004-12-01 EP disclosed
US-6811400-B2 Method for filling and sealing a root canal ULTRADENT PRODUCTS, INC. 2004-11-02 US disclosed
US-6652282-B2 Endodontic sealing compositions and methods for using such compositions ULTRADENT PRODUCTS, INC. 2003-11-25 US disclosed
US-6500004-B2 FOR SEALING A ROOT CANAL; INCLUDE RESINS THAT PROMOTE ADHESION TO HYDROPHILIC DENTAL TISSUES SUCH AS ALKYL METHACRYLATES AND DERIVATIVES THEREOF, SUCH AS OXYPHOSPHORO METHACRYLATES ULTRADENT PRODUCTS, INC. 2002-12-31 US disclosed
WO-2002047572-A1 ENDODONTIC SEALING COMPOSITIONS AND METHODS FOR USING SUCH COMPOSITIONS ULTRADENT PRODUCTS, INC. (US) 2002-06-20 WO disclosed
US-6309221-B1 A KIT INCLUDING PROPYLHEXEDRINE AND AT LEAST ONE IN-SITU POLYMERIZABLE MONOMER (PREFERABLY A PHOPHOALKYL ESTER OF METHACRYLIC ACID) CAPABLE OF ADHERING TO DENTIN AND BECOMING A BARRIER TO MICROORGANISMS ULTRADENT PRODUCTS, INC. 2001-10-30 US disclosed
US-6071528-A CURABLE PHOSPHATE OR PHOSPHONATE ESTER OF (POLY)HYDROXYALKYL METHACRYLATE MONOMER; BONDING AND TENSILE STRENGTH; ULTRADENT PRODUCTS, INC. (US) 2000-06-06 US disclosed
EP-0981273-A1 ADHESIVE, ANTIMICROBIAL AND/OR REPARATIVE DENTIN STIMULATING DENTAL COMPOSITIONS AND METHODS FOR FORMING AND USING SUCH COMPOSITIONS Ultradent Products, Inc. (US) 2000-03-01 EP disclosed
WO-1998036639-A1 ADHESIVE, ANTIMICROBIAL AND/OR REPARATIVE DENTIN STIMULATING DENTAL COMPOSITIONS AND METHODS FOR FORMING AND USING SUCH COMPOSITIONS ULTRADENT PRODUCTS, INC. (US) 1998-08-27 WO disclosed