Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of Methacrylic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.38 |
| ▸ | TET2 | Q6N021 | 4/20 | 0.33 |
| ▸ | PEPD | P12955 | 1/20 | 0.32 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.32 |
| ▸ | TET3 | O43151 | 1/20 | 0.31 |
| ▸ | TET1 | Q8NFU7 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | GABRR1 | P24046 | 1/20 | 0.30 |
| ▸ | GABBR2 | O75899 | 1/20 | 0.30 |
| ▸ | GABBR1 | Q9UBS5 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Methacrylic Acid SCHEMBL25371236 | 1.00 | LMNA (0.39) | LMNAALDH1A1TGFBR1TET2PEPD | |
| Methacrylic Acid SCHEMBL890487 | 1.00 | LMNA (0.39) | LMNAALDH1A1TGFBR1TET2PEPD | |
| Methacrylic Acid SCHEMBL2989895 | 1.00 | LMNA (0.39) | LMNAALDH1A1TGFBR1TET2PEPD | |
| Methacrylic Acid SCHEMBL18043470 | 1.00 | LMNA (0.39) | LMNAALDH1A1TGFBR1TET2PEPD | |
| Methacrylic Acid SCHEMBL11475402 | 0.92 | TGFBR1 (0.36) | LMNAALDH1A1TGFBR1TET2PEPD | |
| Methacrylic Acid SCHEMBL35386 | 0.91 | LMNA (0.47) | LMNAALDH1A1TGFBR1TET2OR51E2 | |
| Methacrylic Acid SCHEMBL35508 | 0.91 | LMNA (0.47) | LMNAALDH1A1TGFBR1TET2OR51E2 | |
| Methacrylic Acid SCHEMBL11414820 | 0.91 | LMNA (0.47) | LMNAALDH1A1TGFBR1TET2OR51E2 | |
| Methacrylic Acid SCHEMBL5710041 | 0.91 | LMNA (0.47) | LMNAALDH1A1TGFBR1TET2OR51E2 | |
| Methacrylic Acid SCHEMBL15733068 | 0.91 | LMNA (0.47) | LMNAALDH1A1TGFBR1TET2OR51E2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 411 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250017827-A1 | Acid-Stable Glass Fillers And Self-Adhesive Dental Composite Cements With Good Transparency Containing Them | IVOCLAR VIVADENT AG (LI) | 2025-01-16 | — | — | US | claimed |
| EP-4488243-A1 | ACID-STABLE GLASS FILLERS AND SELF-ADHESIVE DENTAL COMPOSITE CEMENTS CONTAINING SAME HAVING GOOD TRANSPARENCY | Ivoclar Vivadent AG (LI) | 2025-01-08 | — | — | EP | claimed |
| CN-118879207-A | High temperature resistant acrylate adhesives | 伊利诺斯工具制品有限公司 | 2024-11-01 | — | — | CN | claimed |
| CN-117503616-B | Self-adhesive resin water heater with self-curing stability and preparation method thereof | 日照沪鸽生物材料有限公司 | 2024-10-22 | — | — | CN | claimed |
| EP-3265046-B1 | STABILIZED CALCIUM PHOSPHATE AND METHODS OF FORMING SAME | Modern Ideas LLC (US) | 2024-09-04 | — | — | EP | claimed |
| US-20240279516-A1 | HIGH TEMPERATURE RESISTANT ACRYLIC ADHESIVE | ILLINOIS TOOL WORKS INC. (US) | 2024-08-22 | — | — | US | claimed |
| US-11998409-B2 | Dental composite blank and method for manufacturing same | VERICOM CO., LTD. (KR) | 2024-06-04 | — | — | US | claimed |
| US-11992538-B2 | Polymerizable dental composition based on condensed silanes | VOCO GMBH (DE) | 2024-05-28 | — | — | US | claimed |
| US-20240158614-A1 | STORAGE STABLE SELF-ADHESIVE COMPOSITE CEMENTS WITH GOOD TRANSPARENCY AND GOOD RADIOPACITY | IVOCLAR VIVADENT AG (LI) | 2024-05-16 | — | — | US | claimed |
| EP-4356893-A1 | STORAGE STABLE SELF-ADHESIVE COMPOSITE CEMENTS WITH GOOD TRANSPARENCY AND GOOD RADIOPACITY | Ivoclar Vivadent AG (LI) | 2024-04-24 | — | — | EP | claimed |
| EP-1496837-A1 | MEDICAL COMPOSITIONS CONTAINING AN IONIC SALT | 3M Innovative Properties Company (US) | 2005-01-19 | — | — | EP | claimed |
| EP-1458831-A2 | COMPOSITION CONTAINING A POLYMERIZABLE REDUCING AGENT, KIT, AND METHOD | 3M Innovative Properties Company (US) | 2004-09-22 | — | — | EP | claimed |
| WO-2003086328-A1 | MEDICAL COMPOSITIONS CONTAINING AN IONIC SALT | 3M INNOVATIVE PROPERTIES COMPANY (US) | 2003-10-23 | — | — | WO | claimed |
| US-20030195273-A1 | Medical compositions containing an ionic salt, kits, and methods | 3M INNOVATIVE PROPERTIES COMPANY | 2003-10-16 | — | — | US | claimed |
| US-20030166740-A1 | Composition containing a polymerizable reducing agent, kit, and method | 3M INNOVATIVE PROPERTIES COMPANY | 2003-09-04 | — | — | US | claimed |
| WO-2003057792-A2 | COMPOSITION CONTAINING A POLYMERIZABLE REDUCING AGENT, KIT, AND METHOD | 3M INNOVATIVE PROPERTIES COMPANY (US) | 2003-07-17 | — | — | WO | claimed |
| EP-1282388-A4 | POLYMERIZABLE DISPERSANT | KERR CORP (US) | 2003-06-04 | — | — | EP | claimed |
| EP-1282388-A1 | POLYMERIZABLE DISPERSANT | Kerr Corporation (US) | 2003-02-12 | — | — | EP | claimed |
| US-6359090-B1 | FOR PRODUCING CURED ARTICLES HAVING REDUCED SHRINKAGE, A LOWER COEFFICIENT OF THERMAL EXPANSION AND IMPROVED PHYSICAL PROPERTIES | KERR CORPORATION | 2002-03-19 | — | — | US | claimed |
| WO-2001087242-A1 | POLYMERIZABLE DISPERSANT | KERR CORPORATION (US) | 2001-11-22 | — | — | WO | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11992538-B2 | Polymerizable dental composition based on condensed silanes | NCAPH, RCC1, NCAPD2 | LMNA 322/4885ALDH1A1 1481/4885TGFBR1 2356/4885 |
| US-20030195273-A1 | Medical compositions containing an ionic salt, kits, and methods | NOX4, SCN4A, IL4 | LMNA 2934/4885ALDH1A1 1883/4885TGFBR1 1599/4885 |
| US-20250017827-A1 | Acid-Stable Glass Fillers And Self-Adhesive Dental Composite Cements With Good Transparency Containing Them | HAO2, HAO1, CDH1 | LMNA 2791/4885ALDH1A1 1494/4885TGFBR1 3310/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.