Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of Methacrylic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.38 |
| ▸ | TET2 | Q6N021 | 4/20 | 0.33 |
| ▸ | PEPD | P12955 | 1/20 | 0.32 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.32 |
| ▸ | TET3 | O43151 | 1/20 | 0.31 |
| ▸ | TET1 | Q8NFU7 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | GABRR1 | P24046 | 1/20 | 0.30 |
| ▸ | GABBR2 | O75899 | 1/20 | 0.30 |
| ▸ | GABBR1 | Q9UBS5 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Methacrylic Acid SCHEMBL25371236 | 1.00 | LMNA (0.39) | LMNAALDH1A1TGFBR1TET2PEPD | |
| Methacrylic Acid SCHEMBL243352 | 1.00 | LMNA (0.39) | LMNAALDH1A1TGFBR1TET2PEPD | |
| Methacrylic Acid SCHEMBL2989895 | 1.00 | LMNA (0.39) | LMNAALDH1A1TGFBR1TET2PEPD | |
| Methacrylic Acid SCHEMBL18043470 | 1.00 | LMNA (0.39) | LMNAALDH1A1TGFBR1TET2PEPD | |
| Methacrylic Acid SCHEMBL11475402 | 0.92 | TGFBR1 (0.36) | LMNAALDH1A1TGFBR1TET2PEPD | |
| Methacrylic Acid SCHEMBL35386 | 0.91 | LMNA (0.47) | LMNAALDH1A1TGFBR1TET2OR51E2 | |
| Methacrylic Acid SCHEMBL35508 | 0.91 | LMNA (0.47) | LMNAALDH1A1TGFBR1TET2OR51E2 | |
| Methacrylic Acid SCHEMBL11414820 | 0.91 | LMNA (0.47) | LMNAALDH1A1TGFBR1TET2OR51E2 | |
| Methacrylic Acid SCHEMBL5710041 | 0.91 | LMNA (0.47) | LMNAALDH1A1TGFBR1TET2OR51E2 | |
| Methacrylic Acid SCHEMBL15733068 | 0.91 | LMNA (0.47) | LMNAALDH1A1TGFBR1TET2OR51E2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 38 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7828550-B2 | Activating endodontic points and dental tools for initiating polymerization of dental compositions | ULTRADENT PRODUCTS, INC. (US) | 2010-11-09 | — | — | US | claimed |
| EP-1926448-A2 | COMPOSITIONS, KITS AND METHODS FOR INITIATING OR ACCELERATING CURING OF ENDODONTIC FILLER OR SEALER COMPOSITIONS PLACED ON A ROOT CANAL | Ultradent Products, Inc. (US) | 2008-06-04 | — | — | EP | claimed |
| WO-2007038051-A2 | COMPOSITIONS, KITS AND METHODS FOR INITIATING OR ACCELERATING CURING OF ENDODONTIC FILLER OR SEALER COMPOSITIONS PLACED ON A ROOT CANAL | ULTRADENT PRODUCTS, INC. (US) | 2007-04-05 | — | — | WO | claimed |
| US-20070065781-A1 | Activating endodontic points and dental tools for initiating polymerization of dental compositions | ULTRADENT PRODUCTS, INC. | 2007-03-22 | — | — | US | claimed |
| US-6811400-B2 | Method for filling and sealing a root canal | ULTRADENT PRODUCTS, INC. | 2004-11-02 | — | — | US | claimed |
| US-6652282-B2 | Endodontic sealing compositions and methods for using such compositions | ULTRADENT PRODUCTS, INC. | 2003-11-25 | — | — | US | claimed |
| US-20030194682-A1 | Method for filling and sealing a root canal | JENSEN STEVEN D (US) | 2003-10-16 | — | — | US | claimed |
| US-10765492-B2 | Dental veneers and methods of manufacture | Lampl, Stephan (CH) | 2020-09-08 | — | — | US | disclosed |
| US-20180132973-A1 | DENTAL VENEERS AND METHODS OF MANUFACTURE | EDELWEISS DENTISTRY PRODUCTS GMBH (AT) | 2018-05-17 | — | — | US | disclosed |
| US-20170014206-A1 | DENTAL VENEERS AND METHODS OF MANUFACTURE | COLTÈNE/WHALEDENT AG (CH) | 2017-01-19 | — | — | US | disclosed |
| US-8915736-B2 | Composition comprising a monomer with a polyalicyclic structure element for filling and/or sealing a root canal | VOCO GMBH (DE) | 2014-12-23 | — | — | US | disclosed |
| US-RE44917-E1 | Compositions, kits and methods for initiating or accelerating curing of endodontic filler or sealer compositions placed on a root canal | ULTRADENT PRODUCTS, INC. (US) | 2014-05-27 | — | — | US | disclosed |
| EP-2684537-A1 | Compositions, kits, and methods for initiating or accelerating curing of endodontic filler or sealer compositions placed on a root canal | Ultradent Products, Inc. (US) | 2014-01-15 | — | — | EP | disclosed |
| US-6652282-B2 | Endodontic sealing compositions and methods for using such compositions | ULTRADENT PRODUCTS, INC. | 2003-11-25 | — | — | US | disclosed |
| US-20030199605-A1 | Hydrophilic endodontic sealing compositions and methods for using such compositions | ULTRADENT PRODUCTS, INC. | 2003-10-23 | — | — | US | disclosed |
| US-20030194682-A1 | Method for filling and sealing a root canal | JENSEN STEVEN D (US) | 2003-10-16 | — | — | US | disclosed |
| US-6500004-B2 | FOR SEALING A ROOT CANAL; INCLUDE RESINS THAT PROMOTE ADHESION TO HYDROPHILIC DENTAL TISSUES SUCH AS ALKYL METHACRYLATES AND DERIVATIVES THEREOF, SUCH AS OXYPHOSPHORO METHACRYLATES | ULTRADENT PRODUCTS, INC. | 2002-12-31 | — | — | US | disclosed |
| US-20020177100-A1 | Endodontic sealing compositions and methods for using such compositions | JENSEN STEVEN D (US) | 2002-11-28 | — | — | US | disclosed |
| US-20020123024-A1 | Endodontic sealing compositions and methods for using such compositions | ULTRADENT PRODUCTS, INC. | 2002-09-05 | — | — | US | disclosed |
| WO-2002047572-A1 | ENDODONTIC SEALING COMPOSITIONS AND METHODS FOR USING SUCH COMPOSITIONS | ULTRADENT PRODUCTS, INC. (US) | 2002-06-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030199605-A1 | Hydrophilic endodontic sealing compositions and methods for using such compositions | HLCS, NLRP3, ATP5PO | LMNA 1360/4885ALDH1A1 3901/4885TGFBR1 4335/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.