Phosphoric Acid

Phosphoric Acid

SCHEMBL2993370

CC(=CCC(O)CO)C(=O)OCC(O)CO.O=P(O)(O)O

nearest known ligand 0.36

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Known targets — ChEMBL curated mechanism

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

The experimentally established mechanism targets of Phosphoric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 1/20 0.36
DUSP3 P51452 1/20 0.36
MEN1 O00255 1/20 0.36
KMT2A Q03164 1/20 0.36
LMNA P02545 1/20 0.36
DGKA P23743 1/20 0.35
FAAH O00519 2/20 0.33
SMN1; SMN2 Q16637 1/20 0.31
ENPP2 Q13822 4/20 0.31
TRPV1 Q8NER1 1/20 0.31
CYP2D6 P10635 1/20 0.31
CYP2C19 P33261 1/20 0.31
LPAR6 P43657 1/20 0.30
LPAR1 Q92633 1/20 0.30
LPAR4 Q99677 1/20 0.30
LPAR5 Q9H1C0 1/20 0.30
LPAR2 Q9HBW0 1/20 0.30
LPAR3 Q9UBY5 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9333754 0.94 KDM4E (0.40) KDM4EDUSP3MEN1KMT2ALMNA
SCHEMBL11117444 0.86 KDM4E (0.37) KDM4EDUSP3MEN1KMT2ALMNA
SCHEMBL11117446 0.86 KDM4E (0.41) KDM4EDUSP3MEN1KMT2ALMNA
Phosphoric Acid SCHEMBL27901925 0.85 KDM4E (0.39) KDM4EDUSP3MEN1KMT2ALMNA
SCHEMBL28367146 0.79 KDM4E (0.39) KDM4EDUSP3MEN1KMT2ALMNA
SCHEMBL14945 0.78 LMNA (0.43) KDM4EDUSP3MEN1KMT2ALMNA
SCHEMBL28567442 0.78 USP2 (0.35) KDM4EDUSP3MEN1KMT2ALMNA
SCHEMBL28567440 0.78 DGKA (0.46) KDM4EDUSP3MEN1KMT2ALMNA
SCHEMBL28667284 0.78 KDM4E (0.38) KDM4EDUSP3MEN1KMT2ALMNA
Phosphoric Acid SCHEMBL16620209 0.77 TSHR (0.53) KDM4EDUSP3MEN1KMT2ALMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7780449-B2 Hydrophilic endodontic sealing compositions and methods for using such compositions ULTRADENT PRODUCTS, INC. (US) 2010-08-24 US disclosed
US-7320598-B2 Method for filling and sealing a root canal ULTRADENT PRODUCTS, INC. (US) 2008-01-22 US disclosed
US-20050196726-A1 Hydrophilic endodontic sealing compositions and methods for using such compositions ULTRADENT PRODUCTS, INC. 2005-09-08 US disclosed
EP-0981273-A4 ADHESIVE, ANTIMICROBIAL AND/OR REPARATIVE DENTIN STIMULATING DENTAL COMPOSITIONS AND METHODS FOR FORMING AND USING SUCH COMPOSITIONS ULTRADENT PRODUCTS INC (US) 2004-12-01 EP disclosed
US-6811400-B2 Method for filling and sealing a root canal ULTRADENT PRODUCTS, INC. 2004-11-02 US disclosed
US-6652282-B2 Endodontic sealing compositions and methods for using such compositions ULTRADENT PRODUCTS, INC. 2003-11-25 US disclosed
US-6500004-B2 FOR SEALING A ROOT CANAL; INCLUDE RESINS THAT PROMOTE ADHESION TO HYDROPHILIC DENTAL TISSUES SUCH AS ALKYL METHACRYLATES AND DERIVATIVES THEREOF, SUCH AS OXYPHOSPHORO METHACRYLATES ULTRADENT PRODUCTS, INC. 2002-12-31 US disclosed
WO-2002047572-A1 ENDODONTIC SEALING COMPOSITIONS AND METHODS FOR USING SUCH COMPOSITIONS ULTRADENT PRODUCTS, INC. (US) 2002-06-20 WO disclosed
US-6071528-A CURABLE PHOSPHATE OR PHOSPHONATE ESTER OF (POLY)HYDROXYALKYL METHACRYLATE MONOMER; BONDING AND TENSILE STRENGTH; ULTRADENT PRODUCTS, INC. (US) 2000-06-06 US disclosed
EP-0981273-A1 ADHESIVE, ANTIMICROBIAL AND/OR REPARATIVE DENTIN STIMULATING DENTAL COMPOSITIONS AND METHODS FOR FORMING AND USING SUCH COMPOSITIONS Ultradent Products, Inc. (US) 2000-03-01 EP disclosed
WO-1998036639-A1 ADHESIVE, ANTIMICROBIAL AND/OR REPARATIVE DENTIN STIMULATING DENTAL COMPOSITIONS AND METHODS FOR FORMING AND USING SUCH COMPOSITIONS ULTRADENT PRODUCTS, INC. (US) 1998-08-27 WO disclosed