Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4532023 | 1.00 | KDM4E (0.49) | KDM4EALDH1A1MAPK1NPC1LMNA | |
| Formaldehyde SCHEMBL28745971 | 0.97 | KDM4E (0.46) | KDM4EALDH1A1MAPK1NPC1LMNA | |
| SCHEMBL6881055 | 0.84 | KDM4E (0.41) | KDM4EALDH1A1MAPK1NPC1LMNA | |
| SCHEMBL6881052 | 0.84 | KDM4E (0.41) | KDM4EALDH1A1MAPK1NPC1LMNA | |
| SCHEMBL14862534 | 0.83 | KDM4E (0.46) | KDM4EALDH1A1MAPK1NPC1LMNA | |
| SCHEMBL199306 | 0.81 | ALDH1A1 (0.65) | KDM4EALDH1A1MAPK1NPC1LMNA | |
| SCHEMBL7214316 | 0.80 | KDM4E (0.43) | KDM4EALDH1A1MAPK1NPC1LMNA | |
| SCHEMBL31519065 | 0.79 | ALDH1A1 (0.63) | KDM4EALDH1A1MAPK1NPC1LMNA | |
| SCHEMBL28812535 | 0.79 | ALDH1A1 (0.63) | KDM4EALDH1A1MAPK1NPC1LMNA | |
| SCHEMBL13473987 | 0.73 | KDM4E (0.50) | KDM4EALDH1A1MAPK1NPC1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113164459-B | Monoacylglycerol lipase modulators | 詹森药业有限公司 | 2024-09-03 | — | — | CN | claimed |
| US-12577243-B2 | Monoacylglycerol lipase modulators | JANSSEN PHARMACEUTICA NV (BE) | 2026-03-17 | — | — | US | disclosed |
| US-11820766-B2 | Monoacylglycerol lipase modulators | JANSSEN PHARMACEUTICA NV (BE) | 2023-11-21 | — | — | US | disclosed |
| US-20230145249-A1 | Monoacylglycerol Lipase Modulators | JANSSEN PHARMACEUTICA NV (BE) | 2023-05-11 | — | — | US | disclosed |
| US-20220332713-A1 | Monoacylglycerol Lipase Modulators | JANSSEN PHARMACEUTICA NV (BE) | 2022-10-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220332713-A1 | Monoacylglycerol Lipase Modulators | MGLL, LPL, PNLIP | KDM4E 2437/4885ALDH1A1 312/4885MAPK1 4389/4885 |
| US-12577243-B2 | Monoacylglycerol lipase modulators | MGLL, LPL, FAAH | KDM4E 3565/4885ALDH1A1 587/4885MAPK1 4010/4885 |
| US-20230145249-A1 | Monoacylglycerol Lipase Modulators | MGLL, LPL, PNLIP | KDM4E 2437/4885ALDH1A1 312/4885MAPK1 4389/4885 |
| US-11820766-B2 | Monoacylglycerol lipase modulators | MGLL, LPL, PNLIP | KDM4E 2437/4885ALDH1A1 312/4885MAPK1 4389/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.