Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 2/20 | 0.38 |
| ▸ | STING1 | Q86WV6 | 4/20 | 0.36 |
| ▸ | POLA1 | P09884 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | PARP1 | P09874 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27087621 | 1.00 | ALK (0.38) | ALKSTING1POLA1KMT2AMEN1 | |
| SCHEMBL20004206 | 0.79 | ALK (0.38) | ALKKMT2AMEN1ALDH1A1GAA | |
| SCHEMBL897012 | 0.78 | HTR2A (0.45) | ALKKDM4ETSHR | |
| SCHEMBL897525 | 0.78 | ALK (0.43) | ALKALDH1A1GAATSHRMAPK1 | |
| SCHEMBL20061137 | 0.78 | S100B (0.38) | ALKKMT2AALDH1A1GAAPARP1 | |
| SCHEMBL897888 | 0.77 | TAAR1 (0.39) | ALKSTING1POLA1KMT2AMEN1 | |
| SCHEMBL20061173 | 0.75 | S100B (0.38) | ALKKMT2AALDH1A1GAATSHR | |
| SCHEMBL897548 | 0.74 | CA9 (0.43) | ALKKMT2AMEN1ALDH1A1PARP1 | |
| SCHEMBL29940794 | 0.74 | CHEK1 (0.38) | ALKSTING1ALDH1A1KDM4E | |
| SCHEMBL27087561 | 0.74 | CHEK1 (0.38) | ALKSTING1ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115340523-B | Compound with ALK inhibitory activity and preparation method and application thereof | 盛世泰科生物医药技术(苏州)股份有限公司 | 2023-12-15 | — | — | CN | disclosed |
| WO-2022237813-A1 | COMPOUND HAVING ALK INHIBITORY ACTIVITY, PREPARATION METHOD THEREFOR AND USE THEREOF | 盛世泰科生物医药技术(苏州)有限公司 | 2022-11-17 | — | — | WO | disclosed |
| CN-115340523-A | Compound with ALK inhibitory activity and preparation method and application thereof | 盛世泰科生物医药技术(苏州)有限公司 | 2022-11-15 | — | — | CN | disclosed |