Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.33 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.33 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.33 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.33 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.33 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.33 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.33 |
| ▸ | PARP1 | P09874 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL897012 | 0.83 | HTR2A (0.45) | ALK | |
| SCHEMBL20061137 | 0.83 | S100B (0.38) | ALKKMT2AL3MBTL1MAPK1GAA | |
| SCHEMBL897525 | 0.83 | ALK (0.43) | ALKMAPK1GAAALDH1A1 | |
| SCHEMBL897888 | 0.81 | TAAR1 (0.39) | ALKKMT2AMEN1MAPK1ALDH1A1 | |
| SCHEMBL20061173 | 0.79 | S100B (0.38) | ALKKMT2AL3MBTL1GAAALDH1A1 | |
| SCHEMBL29940794 | 0.79 | CHEK1 (0.38) | ALKALDH1A1 | |
| SCHEMBL7812922 | 0.79 | ALK (0.43) | ALKKMT2ASMN1; SMN2ALDH1A1PARP1 | |
| SCHEMBL29940534 | 0.79 | ALK (0.38) | ALKKMT2AMEN1MAPK1GAA | |
| SCHEMBL27087621 | 0.79 | ALK (0.38) | ALKKMT2AMEN1MAPK1GAA | |
| SCHEMBL897548 | 0.79 | CA9 (0.43) | ALKKMT2AMEN1MAPK1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2975024-B1 | TETRACYCLIC COMPOUNDS | CHUGAI PHARMACEUTICAL CO LTD (JP) | 2018-03-28 | — | — | EP | disclosed |