Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.45 |
| ▸ | MAPT | P10636 | 6/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 3/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23630487 | 1.00 | NPC1 (0.54) | NPC1KDM4EMAPTGAATSHR | |
| SCHEMBL23630485 | 0.86 | ALDH1A1 (0.55) | KDM4EMAPTGAASMN1; SMN2HPGD | |
| SCHEMBL29944092 | 0.86 | ALDH1A1 (0.55) | KDM4EMAPTGAASMN1; SMN2HPGD | |
| SCHEMBL30796963 | 0.83 | SMARCA2 (0.46) | NPC1KDM4EMAPTGAAMAPK1 | |
| SCHEMBL29944012 | 0.81 | PIK3CA (0.47) | NPC1KDM4EMAPTRAB9ASMN1; SMN2 | |
| SCHEMBL23630466 | 0.81 | PIK3CA (0.47) | NPC1KDM4EMAPTRAB9ASMN1; SMN2 | |
| SCHEMBL26154642 | 0.77 | NPC1 (0.61) | NPC1KDM4EMAPTGAATSHR | |
| SCHEMBL1490676 | 0.75 | PLOD2 (0.60) | NPC1KDM4EGAAMAPK1TP53 | |
| SCHEMBL5743752 | 0.75 | ALDH1A1 (0.66) | NPC1KDM4EMAPTGAATSHR | |
| SCHEMBL31385756 | 0.74 | HSP90AA1 (0.38) | NPC1KDM4EMAPTPKMALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4087658-A1 | SMARCA2-VHL DEGRADERS | Amgen Inc. (US) | 2022-11-16 | — | — | EP | disclosed |