Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.60 |
| ▸ | PPARA | Q07869 | 2/20 | 0.52 |
| ▸ | CTRB1 | P17538 | 2/20 | 0.49 |
| ▸ | OPRK1 | P41145 | 5/20 | 0.48 |
| ▸ | CTSK | P43235 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 4/20 | 0.48 |
| ▸ | LMNA | P02545 | 4/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.48 |
| ▸ | CNR2 | P34972 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | KLK1 | P06870 | 1/20 | 0.47 |
| ▸ | CCR1 | P32246 | 1/20 | 0.47 |
| ▸ | PTPN7 | P35236 | 2/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.47 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.47 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29944675 | 1.00 | TP53 (0.60) | TP53PPARACTRB1OPRK1CTSK | |
| SCHEMBL4998172 | 0.90 | CTRB1 (0.55) | CTRB1LMNAALDH1A1SMN1; SMN2 | |
| SCHEMBL7134978 | 0.90 | CTRB1 (0.55) | CTRB1LMNAALDH1A1SMN1; SMN2 | |
| SCHEMBL4665558 | 0.90 | CTRB1 (0.55) | CTRB1LMNAALDH1A1SMN1; SMN2 | |
| SCHEMBL12195405 | 0.89 | KLK1 (0.58) | TP53CTRB1OPRK1CTSKMEN1 | |
| SCHEMBL16553624 | 0.86 | CTRB1 (0.49) | TP53CTRB1MEN1LMNAKMT2A | |
| SCHEMBL8162994 | 0.86 | CTRB1 (0.49) | TP53CTRB1MEN1LMNAKMT2A | |
| SCHEMBL12195401 | 0.86 | CTSK (0.49) | CTRB1OPRK1CTSKMEN1LMNA | |
| SCHEMBL12195404 | 0.85 | PRKCA (0.54) | CTSKKLK1 | |
| SCHEMBL1554807 | 0.84 | ATM (0.64) | TP53CTSKCNR2ALDH1A1KLK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11479533-B2 | Inhibitors of Rho associated coiled-coil containing protein kinase | KADMON CORPORATION, LLC (US) | 2022-10-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11479533-B2 | Inhibitors of Rho associated coiled-coil containing protein kinase | ROCK1, ROCK2, RHOT2 | TP53 2687/4885PPARA 4775/4885CTRB1 3340/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.