SCHEMBL299472

SCHEMBL299472

O=C(Nc1c(Cl)cc(C(F)(C(F)(F)F)C(F)(F)C(F)(F)F)cc1Cl)c1ccccc1

nearest known ligand 0.55

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
LMNA P02545 3/20 0.47
MEN1 O00255 2/20 0.47
KMT2A Q03164 2/20 0.47
P2RX1 P51575 1/20 0.47
NPC1 O15118 3/20 0.46
RAB9A P51151 3/20 0.46
POLB P06746 1/20 0.44
GAA P10253 1/20 0.44
MRGPRX4 Q96LA9 1/20 0.44
ALDH1A1 P00352 1/20 0.43
KCNH2 Q12809 1/20 0.43
KCNJ11 Q14654 1/20 0.43
KCNK3 O14649 1/20 0.43
TAS1R3 Q7RTX0 1/20 0.42
TAS1R1 Q7RTX1 1/20 0.42
TAS1R2 Q8TE23 1/20 0.42
GLA P06280 1/20 0.42
HPGD P15428 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL299219 0.85 P2RX1 (0.48) LMNAMEN1KMT2AP2RX1NPC1
SCHEMBL299858 0.83 TRPV1 (0.54) LMNAMEN1KMT2ANPC1RAB9A
SCHEMBL31375432 0.83 TRPV1 (0.54) LMNAMEN1KMT2ANPC1RAB9A
SCHEMBL23086317 0.80 RXFP1 (0.49) MEN1KMT2AKCNK3
SCHEMBL9894627 0.80 PTGS1 (0.51) LMNAMEN1KMT2APOLB
SCHEMBL17399545 0.80 ALDH1A1 (0.48) MEN1KMT2ANPC1RAB9APOLB
SCHEMBL297830 0.79 KDM4E (0.43) MEN1KMT2AP2RX1NPC1RAB9A
SCHEMBL1767236 0.78 KCNK3 (0.56) LMNAMEN1KMT2AP2RX1NPC1
SCHEMBL18724342 0.78 MEN1 (0.44) LMNAMEN1KMT2ANPC1RAB9A
SCHEMBL22204030 0.78 TRPV1 (0.51) LMNAMEN1KMT2ANPC1RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2427427-A1 4 -CYANO- 3 -BENZOYLAMINO-N- PHENYL-BENZAMIDES FOR USE IN PEST CONTROL Syngenta Participations AG (CH) 2012-03-14 EP disclosed