Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 2/20 | 0.38 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.38 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.38 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.37 |
| ▸ | ERN1 | O75460 | 2/20 | 0.35 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.34 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.34 |
| ▸ | CA1 | P00915 | 2/20 | 0.34 |
| ▸ | CA9 | Q16790 | 2/20 | 0.34 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
| ▸ | NQO1 | P15559 | 1/20 | 0.34 |
| ▸ | NQO2 | P16083 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | CA12 | O43570 | 1/20 | 0.33 |
| ▸ | IKBKB | O14920 | 1/20 | 0.33 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.33 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.33 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.33 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5148513 | 0.76 | APP (0.57) | APPHSD17B1HSD17B2CYP19A1ERN1 | |
| SCHEMBL27651550 | 0.76 | APP (0.57) | APPHSD17B1HSD17B2CYP19A1ERN1 | |
| SCHEMBL26500221 | 0.74 | APP (0.45) | APPHSD17B1HSD17B2CYP19A1ERN1 | |
| SCHEMBL298901 | 0.74 | KDM4E (0.46) | ALDH1A1 | |
| SCHEMBL290560 | 0.72 | BCL2L1 (0.40) | APPHSD17B1HSD17B2CYP19A1ERN1 | |
| SCHEMBL290274 | 0.72 | RAB9A (0.59) | APPCYP19A1ALDH1A1 | |
| SCHEMBL29732980 | 0.71 | APP (0.63) | APPHSD17B1HSD17B2CYP19A1ERN1 | |
| SCHEMBL845603 | 0.71 | APP (0.63) | APPHSD17B1HSD17B2CYP19A1ERN1 | |
| SCHEMBL26744918 | 0.70 | NPC1 (0.45) | APPHSD17B1HSD17B2CYP19A1CA1 | |
| SCHEMBL288707 | 0.69 | CYP19A1 (0.42) | APPHSD17B1HSD17B2CYP19A1CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2427447-A2 | SMALL MOLECULE INHIBITORS OF INFLUENZA A AND B VIRUS AND RESPIRATORY SYNCYTIAL VIRUS REPLICATION | Pike Pharma GmbH (CH) | 2012-03-14 | — | — | EP | disclosed |
| WO-2010128163-A2 | SMALL MOLECULE INHIBITORS OF INFLUENZA A AND B VIRUS AND RESPIRATORY SYNCYTIAL VIRUS REPLICATION | PIKE PHARMA GMBH (CH) | 2010-11-11 | — | — | WO | disclosed |