Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 3/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | PLA2G2A | P14555 | 2/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.36 |
| ▸ | ABL1 | P00519 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | NAMPT | P43490 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.33 |
| ▸ | JAK1 | P23458 | 3/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23536492 | 0.81 | PDK4 (0.49) | NAMPTJAK1 | |
| SCHEMBL23536514 | 0.80 | BRD4 (0.40) | LMNASMN1; SMN2GAAMAPTTSHR | |
| SCHEMBL29948618 | 0.78 | KMT2A (0.38) | GAAMAPTTSHRCYP3A4CYP2C19 | |
| SCHEMBL29650110 | 0.77 | LMNA (0.47) | LMNAPOLBSMN1; SMN2GAAMAPT | |
| SCHEMBL29684579 | 0.76 | SMN1; SMN2 (0.40) | LMNAPOLBSMN1; SMN2MAPTTDP1 | |
| SCHEMBL8259131 | 0.74 | SMN1; SMN2 (0.50) | LMNAPOLBSMN1; SMN2GAAMAPT | |
| SCHEMBL14144348 | 0.74 | ALDH1A1 (0.54) | LMNAPOLBSMN1; SMN2GAAMAPT | |
| SCHEMBL5460918 | 0.73 | CYP1A2 (0.43) | LMNAPOLBSMN1; SMN2MAPTPLA2G2A | |
| SCHEMBL30606972 | 0.73 | SMN1; SMN2 (0.38) | LMNAPOLBSMN1; SMN2CYP1A2CYP2C19 | |
| SCHEMBL29948559 | 0.72 | CNR1 (0.50) | LMNAPOLBSMN1; SMN2MAPTTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4076423-A1 | TRPML MODULATORS | Casma Therapeutics, Inc. (US) | 2022-10-26 | — | — | EP | disclosed |