Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 3/20 | 0.38 |
| ▸ | TSHR | P16473 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 3/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | EDNRA | P25101 | 5/20 | 0.36 |
| ▸ | EDNRB | P24530 | 2/20 | 0.36 |
| ▸ | MMP2 | P08253 | 1/20 | 0.36 |
| ▸ | MMP3 | P08254 | 1/20 | 0.36 |
| ▸ | MMP9 | P14780 | 1/20 | 0.36 |
| ▸ | MMP8 | P22894 | 1/20 | 0.36 |
| ▸ | MMP13 | P45452 | 1/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23536530 | 0.85 | KIT (0.46) | EDNRAEDNRB | |
| SCHEMBL23536374 | 0.85 | EDNRA (0.42) | KMT2AMEN1TSHRHTTNPSR1 | |
| SCHEMBL29948528 | 0.79 | JAK1 (0.37) | KMT2AGAAALDH1A1MMP2MMP3 | |
| SCHEMBL29948447 | 0.78 | LMNA (0.40) | GAATSHRMAPTHTTNPSR1 | |
| SCHEMBL28867414 | 0.71 | EDNRA (0.45) | KMT2AMEN1TSHRCYP2C9CYP2C19 | |
| SCHEMBL29932046 | 0.71 | EDNRA (0.41) | KMT2AMEN1MAPTALDH1A1EDNRA | |
| Trifluoroacetic Acid SCHEMBL29932128 | 0.69 | P2RY1 (0.39) | KMT2AMEN1TSHRHTTEDNRA | |
| SCHEMBL14144348 | 0.66 | ALDH1A1 (0.54) | KMT2AMEN1GAATSHRMAPT | |
| SCHEMBL5460918 | 0.65 | CYP1A2 (0.43) | KMT2AMAPTALDH1A1CYP3A4CYP2C9 | |
| SCHEMBL29650110 | 0.64 | LMNA (0.47) | KMT2AMEN1GAATSHRMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4076423-A1 | TRPML MODULATORS | Casma Therapeutics, Inc. (US) | 2022-10-26 | — | — | EP | disclosed |