Known targets — ChEMBL curated mechanism
GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BHMGCRMMP1MMP13MMP7MMP8PTGS1PTGS2ileSpolrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.52 |
| ▸ | SLC40A1 | Q9NP59 | 3/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.43 |
| ▸ | SLC22A8 | Q8TCC7 | 1/20 | 0.43 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.43 |
| ▸ | SLC22A11 | Q9NSA0 | 1/20 | 0.43 |
| ▸ | PSEN1 | P49768 | 6/20 | 0.43 |
| ▸ | PSEN2 | P49810 | 6/20 | 0.43 |
| ▸ | APH1B | Q8WW43 | 6/20 | 0.43 |
| ▸ | NCSTN | Q92542 | 6/20 | 0.43 |
| ▸ | APH1A | Q96BI3 | 6/20 | 0.43 |
| ▸ | PSENEN | Q9NZ42 | 6/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.41 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.41 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.41 |
| ▸ | MINK1 | Q8N4C8 | 1/20 | 0.41 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.41 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.36 |
| ▸ | NAMPT | P43490 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2169084 | 0.79 | TRPV4 (0.52) | TRPV4SLC40A1CYP2C9SLC22A6SLC22A8 | |
| SCHEMBL18231250 | 0.79 | KCNH2 (0.55) | TRPV4SLC40A1CYP2C9SLC22A6SLC22A8 | |
| SCHEMBL30845950 | 0.79 | TRPV4 (0.52) | TRPV4SLC40A1CYP2C9SLC22A6SLC22A8 | |
| SCHEMBL3701877 | 0.79 | KDM4E (0.57) | TRPV4SLC40A1CYP2C9SLC22A6SLC22A8 | |
| SCHEMBL244098 | 0.79 | TRPV4 (0.52) | TRPV4SLC40A1CYP2C9SLC22A6SLC22A8 | |
| SCHEMBL29948975 | 0.79 | TRPV4 (0.52) | TRPV4SLC40A1CYP2C9SLC22A6SLC22A8 | |
| Hydrochloric Acid SCHEMBL29970288 | 0.78 | TRPV4 (0.50) | TRPV4SLC40A1CYP2C9SLC22A6SLC22A8 | |
| SCHEMBL5077872 | 0.78 | KDM4E (0.55) | TRPV4SLC40A1CYP2C9SLC22A6SLC22A8 | |
| SCHEMBL24590154 | 0.76 | TRPV4 (0.48) | TRPV4SLC40A1CYP2C9SLC22A6SLC22A8 | |
| SCHEMBL24549326 | 0.76 | ALDH1A1 (0.51) | TRPV4SLC40A1CYP2C9SLC22A6SLC22A8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1497374-B1 | FILLER REINFORCED POLYETHER IMIDE RESIN COMPOSITION AND MOLDED ARTICLE THEREOF | GEN ELECTRIC (US) | 2008-08-13 | — | — | EP | disclosed |
| US-7244778-B2 | Filler reinforced polyether imide resin composition and molded article thereof | GENERAL ELECTRIC COMPANY (US) | 2007-07-17 | — | — | US | disclosed |
| CN-1314761-C | Filler reinforced polyether imide resin composition and molded article thereof | GEN ELECTRIC (US) | 2007-05-09 | — | — | CN | disclosed |
| CN-1659234-A | filler-reinforced polyetherimide resin composition and molded article thereof | GEN ELECTRIC (US) | 2005-08-24 | — | — | CN | disclosed |
| US-20050131105-A1 | Filler reinforced polyether imide resin composition and molded article thereof | SHPP GLOBAL TECHNOLOGIES B.V. (NL) | 2005-06-16 | — | — | US | disclosed |