Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.72 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.72 |
| ▸ | LTA4H | P09960 | 4/20 | 0.61 |
| ▸ | FFAR1 | O14842 | 4/20 | 0.61 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.56 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.56 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.55 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.55 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.55 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.55 |
| ▸ | MMP12 | P39900 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.53 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.53 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.53 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.53 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.53 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5720973 | 1.00 | KMT2A (0.72) | KMT2ASMN1; SMN2LTA4HFFAR1PARP10 | |
| Hydrochloric Acid SCHEMBL5207164 | 0.98 | KMT2A (0.71) | KMT2ASMN1; SMN2LTA4HFFAR1PARP10 | |
| SCHEMBL2985256 | 0.86 | MAOB (0.56) | KMT2ASMN1; SMN2LTA4HFFAR1PARP10 | |
| Hydrochloric Acid SCHEMBL6160160 | 0.85 | KMT2A (0.54) | KMT2ASMN1; SMN2LTA4HFFAR1PARP10 | |
| Hydrochloric Acid SCHEMBL8324561 | 0.85 | MAOB (0.55) | KMT2ASMN1; SMN2LTA4HFFAR1PARP10 | |
| Hydrochloric Acid SCHEMBL6158979 | 0.85 | MAOB (0.55) | KMT2ASMN1; SMN2LTA4HFFAR1PARP10 | |
| SCHEMBL8182251 | 0.84 | FFAR1 (0.66) | KMT2ASMN1; SMN2LTA4HFFAR1NR4A1 | |
| SCHEMBL3983305 | 0.84 | FFAR1 (0.64) | KMT2ASMN1; SMN2LTA4HFFAR1NR4A1 | |
| SCHEMBL8771189 | 0.83 | FFAR1 (0.63) | KMT2ASMN1; SMN2LTA4HFFAR1PARP10 | |
| SCHEMBL10317574 | 0.83 | FFAR1 (0.63) | KMT2ASMN1; SMN2LTA4HFFAR1PARP10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2083011-B1 | PYRROLINE DERIVATIVES AGAINST CELL RELEASING TUMOR NECROSIS FACTOR, PREPARATION METHODS AND USES THEREOF | TIANJIN HEMAY BIO TECH CO LTD (CN) | 2014-06-04 | — | — | EP | disclosed |
| US-8466191-B2 | Pyrroline derivatives against cell releasing tumor necrosis factor, preparation methods and uses thereof | ZHANG HESHENG (CN) | 2013-06-18 | — | — | US | disclosed |
| US-20100179189-A1 | PYRROLINE DERIVATIVES AGAINST CELL RELEASING TUMOR NECROSIS FACTOR, PREPARATION METHODS AND USES THEREOF | ZHANG HESHENG | 2010-07-15 | — | — | US | disclosed |
| WO-2010006954-A1 | NOVEL N-SUBSTITUTED BETA-AMINO ACID ESTERS | DSM IP ASSETS B.V. (NL) | 2010-01-21 | — | — | WO | disclosed |
| EP-2083011-A1 | PYRROLINE DERIVATIVES AGAINST CELL RELEASING TUMOR NECROSIS FACTOR, PREPARATION METHODS AND USES THEREOF | Tian Jin Hemay Bio-Tech Co., Ltd. (CN) | 2009-07-29 | — | — | EP | disclosed |
| US-20060178433-A1 | 3-Amino-3-arylpropionic acid n-alkyl esters, process for production thereof, and process for production of optically active 3-amino-3-arylpropionic acids and esters of the antipodes thereto | UBE INDUSTRIES, LTD. (JP) | 2006-08-10 | — | — | US | disclosed |
| EP-1621529-A1 | 3-AMINO-3-ARYLPROPIONIC ACID n-ALKYL ESTERS, PROCESS FOR PRODUCTION THEREOF, AND PROCESS FOR PRODUCTION OF OPTICALLY ACTIVE 3-AMINO-3-ARYLPROPIONIC ACIDS AND ESTERS OF THE ANTIPODES THERETO | Ube Industries, Ltd. (JP) | 2006-02-01 | — | — | EP | disclosed |
| US-20050137408-A1 | Process for producing aminoepoxide | AJINOMOTO CO. INC (JP) | 2005-06-23 | — | — | US | disclosed |
| EP-1505065-A1 | PROCESS FOR PRODUCING AMINOEPOXIDE | Ajinomoto Co., Inc. (JP) | 2005-02-09 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060178433-A1 | 3-Amino-3-arylpropionic acid n-alkyl esters, process for production thereof, and process for production of optically active 3-amino-3-arylpropionic acids and esters of the antipodes thereto | ALAD, ARSA, ALDH7A1 | KMT2A 4127/4885SMN1; SMN2 3856/4885LTA4H 1329/4885 |
| US-20100179189-A1 | PYRROLINE DERIVATIVES AGAINST CELL RELEASING TUMOR NECROSIS FACTOR, PREPARATION METHODS AND USES THEREOF | TNF, IL1B, NOS1 | KMT2A 4801/4885SMN1; SMN2 2069/4885LTA4H 1066/4885 |
| US-20050137408-A1 | Process for producing aminoepoxide | HAO2, DAO, HAAO | KMT2A 745/4885SMN1; SMN2 1572/4885LTA4H 220/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.