Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LIPE | Q05469 | 1/20 | 0.54 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.53 |
| ▸ | ENPP2 | Q13822 | 2/20 | 0.50 |
| ▸ | HTR2C | P28335 | 3/20 | 0.44 |
| ▸ | PDE4A | P27815 | 2/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.40 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.40 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.40 |
| ▸ | ORAI1 | Q96D31 | 1/20 | 0.40 |
| ▸ | ORAI2 | Q96SN7 | 1/20 | 0.40 |
| ▸ | ORAI3 | Q9BRQ5 | 1/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | PDE5A | O76074 | 1/20 | 0.39 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.39 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.39 |
| ▸ | MRGPRX1 | Q96LB2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1852768 | 1.00 | LIPE (0.54) | LIPERIPK1ENPP2HTR2CPDE4A | |
| SCHEMBL29957281 | 0.92 | LIPE (0.50) | LIPERIPK1ENPP2HTR2C | |
| SCHEMBL29953556 | 0.89 | LIPE (0.47) | LIPERIPK1ENPP2HTR2CALDH1A1 | |
| SCHEMBL16034960 | 0.81 | HTR2A (0.48) | RIPK1HTR2CPDE4APDE4BPDE4C | |
| SCHEMBL15068105 | 0.80 | HTR2A (0.50) | RIPK1HTR2CPDE4APDE4BPDE4C | |
| SCHEMBL29957952 | 0.77 | BRD4 (0.47) | LIPESLC6A2SLC6A4SLC6A3ALDH1A1 | |
| SCHEMBL10066572 | 0.76 | ALDH1A1 (0.65) | RIPK1HTR2CALDH1A1GLA | |
| SCHEMBL29993440 | 0.76 | CHRNB4 (0.58) | RIPK1HTR2CPDE4APDE4BPDE4C | |
| SCHEMBL3725334 | 0.76 | GAA (0.55) | RIPK1HTR2CPDE4APDE4BPDE4C | |
| SCHEMBL256797 | 0.76 | ALDH1A1 (0.65) | RIPK1HTR2CALDH1A1GLA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119677737-A | Heteroaryl compounds for the treatment of pain | 沃泰克斯药物股份有限公司 | 2025-03-21 | — | — | CN | disclosed |
| EP-4511116-A1 | HETEROARYL COMPOUNDS FOR THE TREATMENT OF PAIN | Vertex Pharmaceuticals Incorporated (US) | 2025-02-26 | — | — | EP | disclosed |
| WO-2023205463-A1 | HETEROARYL COMPOUNDS FOR THE TREATMENT OF PAIN | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2023-10-26 | — | — | WO | disclosed |
| US-20220340893-A1 | BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES | NUEVOLUTION A/S (DK) | 2022-10-27 | — | — | US | disclosed |