Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | ALOX5AP | P20292 | 2/20 | 0.42 |
| ▸ | MAOB | P27338 | 2/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | DHODH | Q02127 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 4/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13248365 | 0.87 | MEN1 (0.56) | ADAMTS4NPC1RAB9APARP10SMN1; SMN2 | |
| SCHEMBL2245019 | 0.85 | NPC1 (0.47) | NPC1RAB9APARP10SMN1; SMN2MAOB | |
| SCHEMBL2246846 | 0.84 | NPC1 (0.53) | ADAMTS4NPC1RAB9APARP10SMN1; SMN2 | |
| SCHEMBL13248366 | 0.83 | NPSR1 (0.45) | NPC1RAB9APARP10SMN1; SMN2KDM4E | |
| SCHEMBL2251349 | 0.80 | PARP10 (0.57) | ADAMTS4PARP10SMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL13248369 | 0.78 | KDM4C (0.47) | ADAMTS4PARP10ALDH1A1HPGDALOX5AP | |
| SCHEMBL2992851 | 0.78 | PARP10 (0.57) | ADAMTS4NPC1RAB9APARP10SMN1; SMN2 | |
| SCHEMBL2253252 | 0.77 | PARP10 (0.74) | ADAMTS4PARP10SMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL5660242 | 0.77 | YAP1 (0.42) | KDM4EALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL5660237 | 0.76 | ALOX5 (0.36) | ADAMTS4NPC1RAB9APARP10SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100190761-A1 | DIPHENYL SUBSTITUTED ALKANES | MERCK SHARP & DOHME CORP. | 2010-07-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100190761-A1 | DIPHENYL SUBSTITUTED ALKANES | ALOX5, ALOX15, ALOX15B | ADAMTS4 1336/4885NPC1 603/4885RAB9A 4316/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.