Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 1/20 | 0.38 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.38 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.36 |
| ▸ | NOS3 | P29474 | 4/20 | 0.36 |
| ▸ | NOS1 | P29475 | 4/20 | 0.36 |
| ▸ | NOS2 | P35228 | 4/20 | 0.36 |
| ▸ | DPP4 | P27487 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.34 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.34 |
| ▸ | HRH1 | P35367 | 1/20 | 0.34 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8068646 | 0.74 | KDM4E (0.49) | CHRNB2CHRNA4ROCK2KDM4EALDH1A1 | |
| SCHEMBL28852581 | 0.65 | DRD2 (0.57) | LMNAHRH1CYP2D6CYP2C19KDM4E | |
| SCHEMBL7089098 | 0.64 | ALDH1A1 (0.44) | DPP4KDM4EALDH1A1 | |
| SCHEMBL11457404 | 0.63 | KDM4E (0.51) | CHRNB2CHRNA4HRH3KDM4EALDH1A1 | |
| SCHEMBL23579204 | 0.63 | HTR7 (0.56) | CHRNB2CHRNA4ROCK2NOS3NOS1 | |
| SCHEMBL29975085 | 0.63 | HTR7 (0.56) | CHRNB2CHRNA4ROCK2NOS3NOS1 | |
| SCHEMBL1309161 | 0.63 | KDM4E (0.49) | CHRNB2CHRNA4KDM4EALDH1A1 | |
| SCHEMBL30061184 | 0.63 | HTR7 (0.47) | CHRNB2CHRNA4ROCK2LMNAHRH3 | |
| SCHEMBL23861171 | 0.63 | HTR7 (0.47) | CHRNB2CHRNA4ROCK2LMNAHRH3 | |
| SCHEMBL2688407 | 0.63 | MAPT (0.54) | CHRNB2CHRNA4KCNH2HRH3KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115335046-A | Lipoxygenase inhibitors | 思研（SRI）国际顾问与咨询公司 | 2022-11-11 | — | — | CN | disclosed |
| EP-4081199-A2 | LIPOXYGENASE INHIBITORS | SRI International (US) | 2022-11-02 | — | — | EP | disclosed |
| CN-115135316-A | Lipoxygenase inhibitors | 思研（SRI）国际顾问与咨询公司 | 2022-09-30 | — | — | CN | disclosed |