Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 2/20 | 0.36 |
| ▸ | AR | P10275 | 1/20 | 0.35 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.35 |
| ▸ | GRM5 | P41594 | 1/20 | 0.34 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.34 |
| ▸ | HTR1A | P08908 | 1/20 | 0.34 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.34 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.34 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.33 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3014074 | 0.78 | MEN1 (0.41) | NOTUMDDB1CRBN | |
| SCHEMBL2997925 | 0.78 | MEN1 (0.41) | NOTUMDDB1CRBN | |
| SCHEMBL3006586 | 0.78 | MEN1 (0.41) | NOTUMDDB1CRBN | |
| SCHEMBL3003057 | 0.75 | L3MBTL1 (0.40) | NOTUMP2RX7 | |
| SCHEMBL3001942 | 0.75 | HTR7 (0.44) | — | |
| SCHEMBL2998001 | 0.74 | HTR7 (0.41) | DDB1CRBN | |
| SCHEMBL2996862 | 0.74 | MGLL (0.38) | NOTUM | |
| SCHEMBL3012380 | 0.71 | HTR7 (0.46) | NOTUMP2RX7 | |
| SCHEMBL3001198 | 0.69 | ALDH1A1 (0.41) | CRBN | |
| SCHEMBL2998069 | 0.68 | HTR2C (0.34) | P2RX7DDB1CRBN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7544705-B2 | Pyrroloimidazole derivatives, their preparation, pharmaceutical composition containing them, and their use as nootropic agents | NEUROTUNE AG (CH) | 2009-06-09 | — | — | US | claimed |
| EP-1608655-B1 | PYRROLOIMIDAZOLE DERIVATIVES, THEIR PREPARATION, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, AND THEIR USE AS NOOTROPIC AGENTS | NIKEM RESEARCH SRL (IT) | 2008-07-16 | — | — | EP | claimed |
| US-20070027137-A1 | Pyrroloimidazole derivatives, their preparation, pharmaceutical composition containing them, and their use as nootropic agents | NEUROTUNE AG (CH) | 2007-02-01 | — | — | US | claimed |
| US-20100173945-A1 | Compounds with nootropic action, their preparation, pharmaceutical compositions containing them, and use thereof | FARINA CARLO | 2010-07-08 | — | — | US | disclosed |
| US-20100173945-A1 | Compounds with nootropic action, their preparation, pharmaceutical compositions containing them, and use thereof | FARINA CARLO | 2010-07-08 | — | — | US | disclosed |
| US-20100173945-A1 | Compounds with nootropic action, their preparation, pharmaceutical compositions containing them, and use thereof | FARINA CARLO | 2010-07-08 | — | — | US | disclosed |
| US-7732473-B2 | Compounds with nootropic action, their preparation, pharmaceutical compositions containing them, and use thereof | NEUROTUNE AG (CH) | 2010-06-08 | — | — | US | disclosed |
| US-7732473-B2 | Compounds with nootropic action, their preparation, pharmaceutical compositions containing them, and use thereof | NEUROTUNE AG (CH) | 2010-06-08 | — | — | US | disclosed |
| US-7732473-B2 | Compounds with nootropic action, their preparation, pharmaceutical compositions containing them, and use thereof | NEUROTUNE AG (CH) | 2010-06-08 | — | — | US | disclosed |
| US-20090163565-A1 | Compounds with nootropic action, their preperation, pharmaceutical compositions containing them, and use thereof | FARINA CARLO | 2009-06-25 | — | — | US | disclosed |
| US-20090163565-A1 | Compounds with nootropic action, their preperation, pharmaceutical compositions containing them, and use thereof | FARINA CARLO | 2009-06-25 | — | — | US | disclosed |
| US-20090163565-A1 | Compounds with nootropic action, their preperation, pharmaceutical compositions containing them, and use thereof | FARINA CARLO | 2009-06-25 | — | — | US | disclosed |
| US-7544705-B2 | Pyrroloimidazole derivatives, their preparation, pharmaceutical composition containing them, and their use as nootropic agents | NEUROTUNE AG (CH) | 2009-06-09 | — | — | US | disclosed |
| US-7544705-B2 | Pyrroloimidazole derivatives, their preparation, pharmaceutical composition containing them, and their use as nootropic agents | NEUROTUNE AG (CH) | 2009-06-09 | — | — | US | disclosed |
| US-7544705-B2 | Pyrroloimidazole derivatives, their preparation, pharmaceutical composition containing them, and their use as nootropic agents | NEUROTUNE AG (CH) | 2009-06-09 | — | — | US | disclosed |
| EP-1608655-B1 | PYRROLOIMIDAZOLE DERIVATIVES, THEIR PREPARATION, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, AND THEIR USE AS NOOTROPIC AGENTS | NIKEM RESEARCH SRL (IT) | 2008-07-16 | — | — | EP | disclosed |
| US-20070027137-A1 | Pyrroloimidazole derivatives, their preparation, pharmaceutical composition containing them, and their use as nootropic agents | NEUROTUNE AG (CH) | 2007-02-01 | — | — | US | disclosed |
| US-20070027137-A1 | Pyrroloimidazole derivatives, their preparation, pharmaceutical composition containing them, and their use as nootropic agents | NEUROTUNE AG (CH) | 2007-02-01 | — | — | US | disclosed |
| US-20070027137-A1 | Pyrroloimidazole derivatives, their preparation, pharmaceutical composition containing them, and their use as nootropic agents | NEUROTUNE AG (CH) | 2007-02-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100173945-A1 | Compounds with nootropic action, their preparation, pharmaceutical compositions containing them, and use thereof | GRIN3B, GRIN3A, GRIN1 | NOTUM 897/4885AR 1688/4885P2RX7 55/4885 |
| US-20090163565-A1 | Compounds with nootropic action, their preperation, pharmaceutical compositions containing them, and use thereof | OPRL1, GRIN3B, GRIN3A | NOTUM 696/4885AR 2188/4885P2RX7 32/4885 |
| US-20070027137-A1 | Pyrroloimidazole derivatives, their preparation, pharmaceutical composition containing them, and their use as nootropic agents | GRIN3A, GRIN1, GRIN3B | NOTUM 662/4885AR 3192/4885P2RX7 23/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.