Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ENPP1 | P22413 | 4/20 | 0.40 |
| ▸ | CTSK | P43235 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | EGLN2 | Q96KS0 | 2/20 | 0.36 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.36 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.36 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.36 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.36 |
| ▸ | SRC | P12931 | 3/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | PRKACA | P17612 | 1/20 | 0.34 |
| ▸ | PRKACG | P22612 | 1/20 | 0.34 |
| ▸ | PRKACB | P22694 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19630056 | 1.00 | ENPP1 (0.40) | ENPP1CTSKGAAKDM4EALDH1A1 | |
| SCHEMBL19781763 | 0.76 | SMN1; SMN2 (0.40) | ENPP1CTSKGAAKDM4EALDH1A1 | |
| SCHEMBL16668807 | 0.72 | NCF1 (0.46) | FGFR4 | |
| SCHEMBL19880529 | 0.71 | ALDH1A1 (0.38) | ENPP1CTSKGAAKDM4EALDH1A1 | |
| SCHEMBL19769046 | 0.71 | CTSK (0.38) | ENPP1CTSKGAAKDM4EALDH1A1 | |
| SCHEMBL4578984 | 0.70 | CTSK (0.42) | CTSKGAAKDM4EALDH1A1HPGD | |
| SCHEMBL13273042 | 0.70 | ALOX5AP (0.41) | KDM4EALDH1A1SRCTP53NPC1 | |
| SCHEMBL4579364 | 0.69 | SMN1; SMN2 (0.45) | CTSKGAAKDM4EALDH1A1HPGD | |
| SCHEMBL25491262 | 0.69 | FGFR4 (0.52) | FGFR4 | |
| SCHEMBL22096880 | 0.69 | SMN1; SMN2 (0.35) | ENPP1CTSKGAAKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113234072-B | FGFR4 inhibitor, preparation method and application thereof | 江苏豪森药业集团有限公司 | 2022-11-04 | — | — | CN | disclosed |
| CN-113105454-B | FGFR4 inhibitor, preparation method and application thereof | 江苏豪森药业集团有限公司 | 2022-10-11 | — | — | CN | disclosed |