Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.40 |
| ▸ | CTSK | P43235 | 1/20 | 0.39 |
| ▸ | ENPP1 | P22413 | 4/20 | 0.38 |
| ▸ | PRKCQ | Q04759 | 4/20 | 0.35 |
| ▸ | PRKCD | Q05655 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.34 |
| ▸ | GAA | P10253 | 3/20 | 0.34 |
| ▸ | HPGD | P15428 | 3/20 | 0.34 |
| ▸ | NPC1 | O15118 | 2/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19880529 | 0.84 | ALDH1A1 (0.38) | SMN1; SMN2CTSKENPP1PRKCQPRKCD | |
| SCHEMBL22096880 | 0.80 | SMN1; SMN2 (0.35) | SMN1; SMN2CTSKENPP1PRKCQPRKCD | |
| SCHEMBL19769046 | 0.80 | CTSK (0.38) | SMN1; SMN2CTSKENPP1PRKCQPRKCD | |
| SCHEMBL19630056 | 0.76 | ENPP1 (0.40) | SMN1; SMN2CTSKENPP1ALDH1A1KDM4E | |
| SCHEMBL29980078 | 0.76 | ENPP1 (0.40) | SMN1; SMN2CTSKENPP1ALDH1A1KDM4E | |
| SCHEMBL19779871 | 0.75 | CTSK (0.34) | SMN1; SMN2CTSKENPP1PRKCQPRKCD | |
| SCHEMBL16668807 | 0.70 | NCF1 (0.46) | FGFR4 | |
| SCHEMBL4578984 | 0.68 | CTSK (0.42) | SMN1; SMN2CTSKPRKCQALDH1A1KDM4E | |
| SCHEMBL4579364 | 0.67 | SMN1; SMN2 (0.45) | SMN1; SMN2CTSKALDH1A1KDM4EGAA | |
| SCHEMBL2551503 | 0.66 | PTGER4 (0.49) | SMN1; SMN2ALDH1A1KDM4EGAAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018013676-A1 | SOMATOSTATIN MODULATORS AND USES THEREOF | Crinetics Pharmaceuticals, Inc. (US) | 2018-01-18 | — | — | WO | disclosed |