Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.64 |
| ▸ | RAB9A | P51151 | 5/20 | 0.54 |
| ▸ | NPC1 | O15118 | 4/20 | 0.54 |
| ▸ | MEN1 | O00255 | 4/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.54 |
| ▸ | HPGD | P15428 | 4/20 | 0.54 |
| ▸ | GAA | P10253 | 3/20 | 0.54 |
| ▸ | MAPT | P10636 | 2/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.49 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.49 |
| ▸ | CDH1 | P12830 | 1/20 | 0.46 |
| ▸ | APC | P25054 | 1/20 | 0.46 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.46 |
| ▸ | TCF7L2 | Q9NQB0 | 1/20 | 0.46 |
| ▸ | MGAM | O43451 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.44 |
| ▸ | HTT | P42858 | 3/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2629411 | 1.00 | TDP1 (0.64) | TDP1RAB9ANPC1MEN1KMT2A | |
| SCHEMBL2629412 | 0.93 | TDP1 (0.64) | TDP1RAB9ANPC1MEN1KMT2A | |
| SCHEMBL30134026 | 0.86 | TDP1 (0.46) | TDP1RAB9ANPC1MEN1KMT2A | |
| SCHEMBL14741522 | 0.85 | KMT2A (0.46) | TDP1RAB9ANPC1KMT2AKDM4E | |
| SCHEMBL11088871 | 0.81 | ALDH1A1 (0.62) | TDP1RAB9ANPC1MEN1KMT2A | |
| SCHEMBL29967657 | 0.79 | TDP1 (0.54) | TDP1RAB9ANPC1MEN1KMT2A | |
| SCHEMBL21863476 | 0.79 | TDP1 (0.54) | TDP1RAB9ANPC1MEN1KMT2A | |
| SCHEMBL22237575 | 0.79 | TDP1 (0.46) | TDP1RAB9ANPC1ALDH1A1KDM4E | |
| SCHEMBL1574747 | 0.79 | TDP1 (0.54) | TDP1RAB9ANPC1MEN1KMT2A | |
| SCHEMBL21264207 | 0.79 | TDP1 (0.54) | TDP1RAB9ANPC1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11597728-B2 | Monoacylglycerol lipase modulators | JANSSEN PHARMACEUTICA NV (BE) | 2023-03-07 | — | — | US | disclosed |
| US-20220315583-A1 | Monoacylglycerol Lipase Modulators | JANSSEN PHARMACEUTICA NV (BE) | 2022-10-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11597728-B2 | Monoacylglycerol lipase modulators | MGLL, LPL, PNLIP | TDP1 1309/4885RAB9A 994/4885NPC1 826/4885 |
| US-20220315583-A1 | Monoacylglycerol Lipase Modulators | MGLL, LPL, PNLIP | TDP1 1309/4885RAB9A 994/4885NPC1 826/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.