Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSL | P07711 | 3/20 | 0.53 |
| ▸ | CTSB | P07858 | 3/20 | 0.53 |
| ▸ | CTSS | P25774 | 3/20 | 0.53 |
| ▸ | CTSD | P07339 | 2/20 | 0.53 |
| ▸ | CTSK | P43235 | 4/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3492480 | 0.88 | CTSS (0.49) | CTSLCTSBCTSSCTSDCTSK | |
| SCHEMBL8235806 | 0.85 | CTSS (0.46) | CTSLCTSBCTSSCTSDCTSK | |
| SCHEMBL25219487 | 0.82 | CTSS (0.50) | CTSLCTSBCTSSCTSDCTSK | |
| SCHEMBL7060009 | 0.82 | CTSS (0.50) | CTSLCTSBCTSSCTSDCTSK | |
| SCHEMBL6843347 | 0.82 | CTSS (0.50) | CTSLCTSBCTSSCTSDCTSK | |
| SCHEMBL17828220 | 0.82 | CTSL (0.50) | CTSLCTSBCTSSCTSDCTSK | |
| SCHEMBL8235904 | 0.80 | CTSS (0.50) | CTSLCTSSCTSKFKBP1AMEN1 | |
| SCHEMBL8235947 | 0.80 | CTSS (0.50) | CTSLCTSSCTSKFKBP1AMEN1 | |
| SCHEMBL23457828 | 0.79 | L3MBTL1 (0.47) | SMN1; SMN2L3MBTL1GLAFKBP1APKM | |
| SCHEMBL23457832 | 0.79 | L3MBTL1 (0.47) | SMN1; SMN2L3MBTL1GLAFKBP1APKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12415789-B2 | Macrocycles comprising a 4-amido-2,4-pentadienoate moiety for the treatment of hypoxic cancers | AARHUS UNIVERSITET (DK) | 2025-09-16 | — | — | US | disclosed |
| US-20230020952-A1 | MACROCYCLES COMPRISING A 4-AMIDO-2,4-PENTADIENOATE MOIETY FOR THE TREATMENT OF HYPOXIC CANCERS | AARHUS UNIVERSITET (DK) | 2023-01-19 | — | — | US | disclosed |
| EP-4069217-A1 | MACROCYCLES COMPRISING A 4-AMIDO-2,4-PENTADIENOATE MOIETY FOR THE TREATMENT OF HYPOXIC CANCERS | Aarhus Universitet (DK) | 2022-10-12 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230020952-A1 | MACROCYCLES COMPRISING A 4-AMIDO-2,4-PENTADIENOATE MOIETY FOR THE TREATMENT OF HYPOXIC CANCERS | DLD, HIF1A, DPYD | CTSL 1909/4885CTSB 1583/4885CTSS 2117/4885 |
| US-12415789-B2 | Macrocycles comprising a 4-amido-2,4-pentadienoate moiety for the treatment of hypoxic cancers | DLD, HIF1A, DPYD | CTSL 1909/4885CTSB 1583/4885CTSS 2117/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.