Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 2/20 | 0.40 |
| ▸ | LOXL2 | Q9Y4K0 | 2/20 | 0.39 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.35 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26918593 | 1.00 | PDE4D (0.40) | PDE4DLOXL2P2RX7MAOBPOLB | |
| SCHEMBL29998784 | 0.82 | ALDH1A1 (0.40) | PDE4DLOXL2P2RX7MAOBALDH1A1 | |
| SCHEMBL26918824 | 0.82 | ALDH1A1 (0.40) | PDE4DLOXL2P2RX7MAOBALDH1A1 | |
| SCHEMBL2393767 | 0.77 | FABP4 (0.39) | LOXL2P2RX7POLBALDH1A1HSD17B10 | |
| SCHEMBL6121928 | 0.77 | HCAR2 (0.43) | LOXL2POLBALDH1A1HSD17B10L3MBTL1 | |
| SCHEMBL6122462 | 0.76 | ALDH1A1 (0.38) | PDE4DLOXL2P2RX7POLBALDH1A1 | |
| SCHEMBL27077029 | 0.75 | ALOX15 (0.41) | LOXL2P2RX7POLBALDH1A1HSD17B10 | |
| SCHEMBL30697188 | 0.75 | ALOX15 (0.41) | LOXL2P2RX7POLBALDH1A1HSD17B10 | |
| SCHEMBL12097960 | 0.73 | CES2 (0.45) | P2RX7ALDH1A1HSD17B10HPGDALOX15 | |
| SCHEMBL26919067 | 0.72 | CYP3A4 (0.40) | PDE4DP2RX7POLBALDH1A1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4288428-A1 | AMIDES AS CBL-B INHIBITORS | Genentech, Inc. (US) | 2023-12-13 | — | — | EP | disclosed |
| WO-2022169998-A1 | AMIDES AS CBL-B INHIBITORS | GENENTECH, INC. (US) | 2022-08-11 | — | — | WO | disclosed |