Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRIM24 | O15164 | 1/20 | 0.40 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.40 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.39 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.39 |
| ▸ | NAPRT | Q6XQN6 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | BLM | P54132 | 1/20 | 0.36 |
| ▸ | AGER | Q15109 | 1/20 | 0.36 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16345329 | 1.00 | TRIM24 (0.40) | TRIM24TRIM33HCRTR1HCRTR2NAPRT | |
| SCHEMBL22130586 | 0.84 | ALDH1A1 (0.40) | HCRTR1HCRTR2NAPRTTDP1MEN1 | |
| SCHEMBL16086240 | 0.83 | SMN1; SMN2 (0.44) | TRIM24TRIM33HCRTR1HCRTR2NAPRT | |
| SCHEMBL307472 | 0.82 | P2RX7 (0.50) | HCRTR1HCRTR2NAPRTTDP1KDM4E | |
| SCHEMBL781008 | 0.82 | NAPRT (0.56) | NAPRTTDP1KMT2AKDM4EALDH1A1 | |
| SCHEMBL1092652 | 0.82 | TRPM8 (0.42) | HCRTR1HCRTR2NAPRTTDP1KDM4E | |
| SCHEMBL257468 | 0.81 | LMNA (0.54) | TDP1MEN1KMT2AL3MBTL1POLB | |
| SCHEMBL306737 | 0.81 | POLB (0.45) | HCRTR1HCRTR2NAPRTTDP1ALDH1A1 | |
| SCHEMBL29865799 | 0.81 | LMNA (0.54) | TDP1MEN1KMT2AL3MBTL1POLB | |
| SCHEMBL3922378 | 0.78 | PARP1 (0.55) | TDP1MEN1KMT2AKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4320132-A1 | OXAZEPINE COMPOUNDS AND USES THEREOF IN THE TREATMENT OF CANCER | Genentech, Inc. (US) | 2024-02-14 | — | — | EP | disclosed |
| WO-2022216762-A1 | OXAZEPINE COMPOUNDS AND USES THEREOF IN THE TREATMENT OF CANCER | GENENTECH, INC. (US) | 2022-10-13 | — | — | WO | disclosed |