SCHEMBL29865799

SCHEMBL29865799

CON(C)C(=O)c1cccnc1Cl

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LMNA P02545 3/20 0.54
SMN1; SMN2 Q16637 1/20 0.54
POLB P06746 3/20 0.46
L3MBTL1 Q9Y468 2/20 0.44
CYP1A2 P05177 2/20 0.43
CYP2C9 P11712 2/20 0.43
CYP2C19 P33261 2/20 0.43
CASP3 P42574 1/20 0.43
SENP8 Q96LD8 1/20 0.43
SENP7 Q9BQF6 1/20 0.43
SENP6 Q9GZR1 1/20 0.43
KMT2A Q03164 6/20 0.43
RXFP1 Q9HBX9 1/20 0.43
TDP1 Q9NUW8 2/20 0.42
MEN1 O00255 4/20 0.42
EGFR P00533 1/20 0.42
RECQL P46063 1/20 0.41
RAB9A P51151 1/20 0.41
NPC1 O15118 1/20 0.41
CYP2D6 P10635 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL257468 1.00 LMNA (0.54) LMNASMN1; SMN2POLBL3MBTL1CYP1A2
SCHEMBL2201670 0.83 SMN1; SMN2 (0.61) LMNASMN1; SMN2POLBL3MBTL1CYP1A2
SCHEMBL1092652 0.82 TRPM8 (0.42) LMNASMN1; SMN2POLBL3MBTL1TDP1
SCHEMBL781008 0.82 NAPRT (0.56) LMNASMN1; SMN2POLBL3MBTL1KMT2A
SCHEMBL307472 0.82 P2RX7 (0.50) LMNASMN1; SMN2POLBL3MBTL1TDP1
SCHEMBL306737 0.81 POLB (0.45) LMNASMN1; SMN2POLBL3MBTL1RXFP1
SCHEMBL30961455 0.81 ATR (0.39) LMNASMN1; SMN2L3MBTL1KMT2ATDP1
SCHEMBL16345329 0.81 TRIM24 (0.40) LMNASMN1; SMN2POLBL3MBTL1KMT2A
SCHEMBL29999839 0.81 TRIM24 (0.40) LMNASMN1; SMN2POLBL3MBTL1KMT2A
SCHEMBL28053754 0.81 ATR (0.39) LMNASMN1; SMN2L3MBTL1KMT2ATDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4532485-A1 TYK2 INHIBITORS AND USES THEREOF Sudo Biosciences Limited (GB) 2025-04-09 EP disclosed
EP-4294806-A1 TYK2 INHIBITORS AND USES THEREOF Sudo Biosciences Limited (GB) 2023-12-27 EP disclosed
WO-2023227946-A1 TYK2 INHIBITORS AND USES THEREOF SUDO BIOSCIENCES LIMITED (GB) 2023-11-30 WO disclosed
WO-2022175746-A1 TYK2 INHIBITORS AND USES THEREOF SUDO BIOSCIENCES LIMITED (GB) 2022-08-25 WO disclosed