Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.39 |
| ▸ | GAA | P10253 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | DCPS | Q96C86 | 4/20 | 0.38 |
| ▸ | DHFR | P00374 | 3/20 | 0.38 |
| ▸ | EIF2AK3 | Q9NZJ5 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | G6PD | P11413 | 1/20 | 0.34 |
| ▸ | MPO | P05164 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.34 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.34 |
| ▸ | RELA | Q04206 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28892669 | 1.00 | MAPT (0.39) | MAPTGAASMN1; SMN2TDP1DCPS | |
| SCHEMBL30002446 | 0.88 | GAA (0.40) | MAPTGAASMN1; SMN2TDP1DCPS | |
| SCHEMBL28892136 | 0.88 | GAA (0.40) | MAPTGAASMN1; SMN2TDP1DCPS | |
| SCHEMBL28892906 | 0.83 | LMNA (0.41) | MAPTGAASMN1; SMN2ALDH1A1KMT2A | |
| SCHEMBL30002548 | 0.79 | SCN1A (0.47) | MAPTGAASMN1; SMN2TDP1RAB9A | |
| SCHEMBL28892526 | 0.79 | SCN1A (0.47) | MAPTGAASMN1; SMN2TDP1RAB9A | |
| SCHEMBL30002661 | 0.76 | MTNR1A (0.43) | KMT2AMEN1MPO | |
| SCHEMBL30002421 | 0.76 | MEN1 (0.47) | MAPTALDH1A1KMT2AKDM4EMEN1 | |
| SCHEMBL30002031 | 0.75 | DHFR (0.38) | MAPTGAASMN1; SMN2TDP1DCPS | |
| SCHEMBL28892709 | 0.75 | KDM4E (0.39) | SMN1; SMN2KDM4EMPOCSF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115232144-B | Nitrogen-containing condensed ring derivative, pharmaceutical composition, and preparation method and application thereof | 长春金赛药业有限责任公司 | 2024-04-02 | — | — | CN | disclosed |
| CN-115232144-A | Nitrogen-containing fused ring derivative, pharmaceutical composition, preparation method and application thereof | 长春金赛药业有限责任公司 | 2022-10-25 | — | — | CN | disclosed |