Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 6/20 | 0.42 |
| ▸ | CASP3 | P42574 | 1/20 | 0.42 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.42 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.42 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 5/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | PTGES | O14684 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | HTR1A | P08908 | 1/20 | 0.39 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.39 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.39 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.37 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28892568 | 1.00 | LMNA (0.42) | LMNACASP3SENP8SENP7SENP6 | |
| SCHEMBL28892906 | 0.90 | LMNA (0.41) | LMNACASP3SENP8SENP7SENP6 | |
| SCHEMBL28892294 | 0.83 | ALDH1A1 (0.52) | LMNAGAAPKMPTGESALDH1A1 | |
| SCHEMBL30001950 | 0.83 | ALDH1A1 (0.52) | LMNAGAAPKMPTGESALDH1A1 | |
| SCHEMBL30002446 | 0.83 | GAA (0.40) | GAAMAPTCYP1A2CYP2D6CYP2C9 | |
| SCHEMBL28892136 | 0.83 | GAA (0.40) | GAAMAPTCYP1A2CYP2D6CYP2C9 | |
| SCHEMBL28893045 | 0.83 | SCN1A (0.46) | LMNACASP3SENP8SENP7SENP6 | |
| SCHEMBL30002055 | 0.83 | SCN1A (0.46) | LMNACASP3SENP8SENP7SENP6 | |
| SCHEMBL30002570 | 0.80 | MEN1 (0.52) | LMNAGAAPKMPTGESALDH1A1 | |
| SCHEMBL28892476 | 0.80 | MEN1 (0.52) | LMNAGAAPKMPTGESALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115232144-B | Nitrogen-containing condensed ring derivative, pharmaceutical composition, and preparation method and application thereof | 长春金赛药业有限责任公司 | 2024-04-02 | — | — | CN | disclosed |
| CN-115232144-A | Nitrogen-containing fused ring derivative, pharmaceutical composition, preparation method and application thereof | 长春金赛药业有限责任公司 | 2022-10-25 | — | — | CN | disclosed |