Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGDS | O60760 | 8/20 | 0.53 |
| ▸ | SLC6A5 | Q9Y345 | 8/20 | 0.50 |
| ▸ | DRD4 | P21917 | 1/20 | 0.49 |
| ▸ | SCN1A | P35498 | 1/20 | 0.47 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.47 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.47 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.46 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3000230 | 0.90 | SLC6A5 (0.58) | SLC6A5DRD4SCN1ASCN5ASCN9A | |
| SCHEMBL3000605 | 0.90 | DRD4 (0.49) | SLC6A5DRD4SCN1ASCN5ASCN9A | |
| SCHEMBL2989774 | 0.89 | PARP10 (0.50) | SLC6A5DRD4 | |
| SCHEMBL2995598 | 0.85 | USP30 (0.47) | DRD4 | |
| SCHEMBL2986509 | 0.84 | ALOX5 (0.46) | HPGDSDRD4 | |
| SCHEMBL2993319 | 0.80 | CHRNA7 (0.48) | — | |
| SCHEMBL2994675 | 0.80 | CHRNA7 (0.48) | — | |
| SCHEMBL2986740 | 0.79 | PARP10 (0.57) | — | |
| SCHEMBL3627614 | 0.78 | SLC6A5 (0.52) | SLC6A5DRD4SCN1ASCN5ASCN9A | |
| SCHEMBL2992095 | 0.77 | PARP10 (0.45) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2546232-A1 | Diphenyl Substituted Alkanes | Merck Sharp & Dohme Corp. (US) | 2013-01-16 | — | — | EP | disclosed |
| US-20100190761-A1 | DIPHENYL SUBSTITUTED ALKANES | MERCK SHARP & DOHME CORP. | 2010-07-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100190761-A1 | DIPHENYL SUBSTITUTED ALKANES | ALOX5, ALOX15, ALOX15B | HPGDS 39/4885SLC6A5 4522/4885DRD4 2509/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.