Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM5A | P29375 | 1/20 | 0.46 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.46 |
| ▸ | ACHE | P22303 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | LATS1 | O95835 | 9/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | XPO1 | O14980 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | LATS2 | Q9NRM7 | 7/20 | 0.37 |
| ▸ | CLK1 | P49759 | 1/20 | 0.36 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.36 |
| ▸ | CDK4 | P11802 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20547728 | 0.85 | LATS1 (0.43) | KDM5AKDM4CACHELATS1LATS2 | |
| SCHEMBL162372 | 0.77 | GAA (0.62) | GAAALDH1A1MAPTCCNE2CDK4 | |
| SCHEMBL29500202 | 0.77 | GAA (0.62) | GAAALDH1A1MAPTCCNE2CDK4 | |
| SCHEMBL26157957 | 0.76 | DCPS (0.55) | ACHELMNACYP1A2CYP3A4CYP2D6 | |
| Hydrochloric Acid SCHEMBL30010992 | 0.75 | GAA (0.60) | GAAALDH1A1MAPTCCNE2CDK4 | |
| SCHEMBL14529396 | 0.73 | CYP1A2 (0.51) | ALDH1A1MAPTLATS1MEN1KMT2A | |
| SCHEMBL250853 | 0.73 | ACHE (0.42) | KDM4CACHELATS1LMNACYP1A2 | |
| SCHEMBL31375861 | 0.70 | LATS1 (0.40) | KDM5AKDM4CLATS1LATS2 | |
| SCHEMBL21875480 | 0.70 | LATS1 (0.61) | LATS1LATS2 | |
| SCHEMBL31391450 | 0.69 | MALT1 (0.43) | KDM5AKDM4CALDH1A1MAPTLATS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4322962-A1 | PHOSPHORUS DERIVATIVES AS NOVEL SOS1 INHIBITORS | Bayer Aktiengesellschaft (DE) | 2024-02-21 | — | — | EP | disclosed |
| WO-2022219035-A1 | PHOSPHORUS DERIVATIVES AS NOVEL SOS1 INHIBITORS | BAYER AKTIENGESELLSCHAFT (DE) | 2022-10-20 | — | — | WO | disclosed |