Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LATS1 | O95835 | 18/20 | 0.43 |
| ▸ | LATS2 | Q9NRM7 | 13/20 | 0.43 |
| ▸ | KDM5A | P29375 | 1/20 | 0.40 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.40 |
| ▸ | ACHE | P22303 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30007569 | 0.85 | KDM5A (0.46) | LATS1LATS2KDM5AKDM4CACHE | |
| SCHEMBL250853 | 0.73 | ACHE (0.42) | LATS1LATS2KDM4CACHE | |
| SCHEMBL26157957 | 0.72 | DCPS (0.55) | ACHE | |
| SCHEMBL5768328 | 0.69 | HASPIN (0.46) | LATS1LATS2KDM4CACHE | |
| SCHEMBL14529396 | 0.67 | CYP1A2 (0.51) | LATS1 | |
| SCHEMBL24668149 | 0.67 | LATS1 (0.41) | LATS1LATS2KDM5AKDM4C | |
| SCHEMBL21875480 | 0.67 | LATS1 (0.61) | LATS1LATS2 | |
| SCHEMBL5768942 | 0.66 | LATS1 (0.38) | LATS1LATS2KDM4CACHE | |
| SCHEMBL31375796 | 0.65 | LATS1 (0.42) | LATS1LATS2ACHE | |
| SCHEMBL31375861 | 0.64 | LATS1 (0.40) | LATS1LATS2KDM5AKDM4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3615537-A2 | 6-6 FUSED BICYCLIC HETEROARYL COMPOUNDS AND THEIR USE AS LATS INHIBITORS | Novartis AG (CH) | 2020-03-04 | — | — | EP | disclosed |
| WO-2018198077-A2 | 6-6 FUSED BICYCLIC HETEROARYL COMPOUNDS AND THEIR USE AS LATS INHIBITORS | NOVARTIS AG (CH) | 2018-11-01 | — | — | WO | disclosed |