Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | APOL1 | O14791 | 3/20 | 0.34 |
| ▸ | FAAH | O00519 | 2/20 | 0.34 |
| ▸ | ACLY | P53396 | 2/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30218352 | 0.92 | FAAH (0.35) | CHRNA7SMN1; SMN2APOL1FAAHUSP2 | |
| SCHEMBL30218286 | 0.91 | POLB (0.36) | CHRNA7POLBFAAHACLYMAPK14 | |
| SCHEMBL30218349 | 0.90 | CHRNA7 (0.36) | CHRNA7POLBFAAHACLYMAPK14 | |
| SCHEMBL30218302 | 0.89 | PARP1 (0.34) | POLB | |
| SCHEMBL30218353 | 0.86 | SMN1; SMN2 (0.38) | CHRNA7SMN1; SMN2POLBAPOL1FAAH | |
| SCHEMBL30218351 | 0.81 | POLB (0.37) | CHRNA7POLBFAAHACLYMAPK14 | |
| SCHEMBL28863434 | 0.72 | APOL1 (0.50) | APOL1 | |
| SCHEMBL10180980 | 0.71 | KMT2A (0.39) | SMN1; SMN2POLBACLY | |
| SCHEMBL9221170 | 0.66 | ACLY (0.50) | FAAHACLY | |
| SCHEMBL29372421 | 0.66 | ELANE (0.40) | SMN1; SMN2ACLY |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115867543-A | Solid forms of an APOL1 inhibitor and methods of use thereof | 弗特克斯药品有限公司 | 2023-03-28 | — | — | CN | disclosed |
| CN-115867532-A | Inhibitors of APOL1 and uses thereof | 弗特克斯药品有限公司 | 2023-03-28 | — | — | CN | disclosed |
| CN-115209894-A | Method for treating APOL-1 dependent focal segmental glomerulosclerosis | 弗特克斯药品有限公司 | 2022-10-18 | — | — | CN | disclosed |