Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 7/20 | 0.47 |
| ▸ | SPHK1 | Q9NYA1 | 6/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | CASP2 | P42575 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | NAAA | Q02083 | 2/20 | 0.41 |
| ▸ | ZDHHC20 | Q5W0Z9 | 1/20 | 0.41 |
| ▸ | ZDHHC2 | Q9UIJ5 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3013442 | 0.98 | EPHX1 (0.50) | EPHX1SPHK1HPGDSMN1; SMN2LMNA | |
| SCHEMBL2997940 | 0.98 | EPHX1 (0.50) | EPHX1SPHK1HPGDSMN1; SMN2LMNA | |
| SCHEMBL2994871 | 0.98 | EPHX1 (0.50) | EPHX1SPHK1HPGDSMN1; SMN2LMNA | |
| SCHEMBL2998347 | 0.95 | CYP3A4 (0.43) | EPHX1SPHK1HPGDSMN1; SMN2LMNA | |
| SCHEMBL3009135 | 0.87 | POLB (0.41) | EPHX1SPHK1HPGDSMN1; SMN2LMNA | |
| SCHEMBL3427647 | 0.83 | SPHK1 (0.54) | EPHX1SPHK1HPGDSMN1; SMN2LMNA | |
| SCHEMBL1236882 | 0.81 | HPGD (0.56) | EPHX1SPHK1HPGDSMN1; SMN2LMNA | |
| SCHEMBL1236881 | 0.81 | HPGD (0.56) | EPHX1SPHK1HPGDSMN1; SMN2LMNA | |
| SCHEMBL1237684 | 0.81 | HPGD (0.56) | EPHX1SPHK1HPGDSMN1; SMN2LMNA | |
| SCHEMBL1237682 | 0.81 | HPGD (0.56) | EPHX1SPHK1HPGDSMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 38 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2168567-B1 | Uses of dithiolane compounds for the photoprotection of the skin, dithiolane compounds and compositions containing same | ORÉAL L (FR) | 2015-12-16 | — | — | EP | claimed |
| US-8617524-B2 | Depigmenting keratin materials utilizing dithiolane compounds | L'OREAL (FR) | 2013-12-31 | — | — | US | claimed |
| EP-2191816-B1 | Depigmentation of keratinic material using specific dithiolanes | OREAL (FR) | 2013-09-18 | — | — | EP | claimed |
| US-8535647-B2 | Cosmetic/sunscreen compositions containing dibenzoylmethane compounds and dithiolane compound photostabilizers therefor | L'OREAL (FR) | 2013-09-17 | — | — | US | claimed |
| US-8530511-B2 | Administration of dithiolane compounds for photoprotecting the skin | L'OREAL (FR) | 2013-09-10 | — | — | US | claimed |
| EP-2174644-B1 | Cosmetic composition comprising a dibenzoylmethane derivative and a dithiolane; Photostabilization of a dibenzoylmethane derivative | OREAL (FR) | 2012-11-14 | — | — | EP | claimed |
| US-20100197759-A1 | Administration of dithiolane compounds for photoprotecting the skin | L'OREAL (FR) | 2010-08-05 | — | — | US | claimed |
| US-20100135942-A1 | Depigmenting keratin materials utilizing dithiolane compounds | L'OREAL (FR) | 2010-06-03 | — | — | US | claimed |
| EP-2191816-A1 | Depigmentation of keratinic material using specific dithiolanes | L'OREAL (FR) | 2010-06-02 | — | — | EP | claimed |
| EP-2174644-A1 | Cosmetic composition comprising a dibenzoylmethane derivative and a dithiolane; Photostabilization of a dibenzoylmethane derivative | L'OREAL (FR) | 2010-04-14 | — | — | EP | claimed |
| US-20100086502-A1 | Cosmetic/sunscreen compositions containing dibenzoylmethane compounds and dithiolane compound photostabilizers therefor | L'OREAL (FR) | 2010-04-08 | — | — | US | claimed |
| EP-2168567-B1 | Uses of dithiolane compounds for the photoprotection of the skin, dithiolane compounds and compositions containing same | ORÉAL L (FR) | 2015-12-16 | — | — | EP | disclosed |
| EP-2168567-B1 | Uses of dithiolane compounds for the photoprotection of the skin, dithiolane compounds and compositions containing same | ORÉAL L (FR) | 2015-12-16 | — | — | EP | disclosed |
| US-8617524-B2 | Depigmenting keratin materials utilizing dithiolane compounds | L'OREAL (FR) | 2013-12-31 | — | — | US | disclosed |
| EP-2191816-B1 | Depigmentation of keratinic material using specific dithiolanes | OREAL (FR) | 2013-09-18 | — | — | EP | disclosed |
| US-20100086502-A1 | Cosmetic/sunscreen compositions containing dibenzoylmethane compounds and dithiolane compound photostabilizers therefor | L'OREAL (FR) | 2010-04-08 | — | — | US | disclosed |
| US-20100086502-A1 | Cosmetic/sunscreen compositions containing dibenzoylmethane compounds and dithiolane compound photostabilizers therefor | L'OREAL (FR) | 2010-04-08 | — | — | US | disclosed |
| US-20100086502-A1 | Cosmetic/sunscreen compositions containing dibenzoylmethane compounds and dithiolane compound photostabilizers therefor | L'OREAL (FR) | 2010-04-08 | — | — | US | disclosed |
| EP-2168567-A1 | Uses of dithiolane compounds for the photoprotection of the skin, dithiolane compounds and compositions containing same | L'Oréal (FR) | 2010-03-31 | — | — | EP | disclosed |
| EP-2168567-A1 | Uses of dithiolane compounds for the photoprotection of the skin, dithiolane compounds and compositions containing same | L'Oréal (FR) | 2010-03-31 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100086502-A1 | Cosmetic/sunscreen compositions containing dibenzoylmethane compounds and dithiolane compound photostabilizers therefor | NOTUM, DDT, FDFT1 | EPHX1 1078/4885SPHK1 3229/4885HPGD 437/4885 |
| US-20100197759-A1 | Administration of dithiolane compounds for photoprotecting the skin | GPX1, GPX4, TXN | EPHX1 2216/4885SPHK1 1456/4885HPGD 71/4885 |
| US-20100135942-A1 | Depigmenting keratin materials utilizing dithiolane compounds | KRT18, NR1D1, RER1 | EPHX1 3504/4885SPHK1 763/4885HPGD 614/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.