Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 1/20 | 0.60 |
| ▸ | GRM3 | Q14832 | 1/20 | 0.55 |
| ▸ | PARP10 | Q53GL7 | 2/20 | 0.53 |
| ▸ | L3MBTL3 | Q96JM7 | 6/20 | 0.53 |
| ▸ | MBTD1 | Q05BQ5 | 4/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.53 |
| ▸ | TP53BP1 | Q12888 | 1/20 | 0.53 |
| ▸ | L3MBTL4 | Q8NA19 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.52 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.52 |
| ▸ | NAMPT | P43490 | 1/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | CA12 | O43570 | 1/20 | 0.49 |
| ▸ | CA1 | P00915 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2993886 | 0.90 | HDAC4 (0.54) | GRM5GRM3PARP10L3MBTL3MBTD1 | |
| SCHEMBL3001302 | 0.86 | MGLL (0.61) | GRM5GRM3L3MBTL3MBTD1L3MBTL1 | |
| SCHEMBL538998 | 0.85 | ALDH1A1 (0.61) | PARP10SMN1; SMN2POLBALDH1A1HPGD | |
| SCHEMBL3004294 | 0.84 | SMN1; SMN2 (0.72) | PARP10SMN1; SMN2NAMPTGAATDP1 | |
| SCHEMBL11007666 | 0.82 | MGLL (0.71) | GRM5POLBALDH1A1HPGD | |
| SCHEMBL5880849 | 0.82 | HPGD (0.68) | GRM5GRM3L3MBTL3MBTD1L3MBTL1 | |
| SCHEMBL12074789 | 0.82 | KMT2A (0.71) | GRM5GRM3L3MBTL3MBTD1L3MBTL1 | |
| SCHEMBL30967272 | 0.82 | HSD11B1 (0.71) | GRM5L3MBTL1SMN1; SMN2GAAPOLB | |
| SCHEMBL306320 | 0.82 | GRM5 (0.60) | GRM5GRM3L3MBTL3MBTD1L3MBTL1 | |
| SCHEMBL8161941 | 0.82 | MGLL (0.61) | GRM5GRM3L3MBTL3MBTD1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100190773-A1 | Anti-Cytokine Heterocyclic Compounds | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-07-29 | — | — | US | claimed |
| US-20060276496-A1 | Anti-Cytokine Heterocyclic Compounds | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2006-12-07 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060276496-A1 | Anti-Cytokine Heterocyclic Compounds | MAPKAPK2, MAP4K2, MAP3K2 | GRM5 4379/4885GRM3 4506/4885PARP10 1443/4885 |
| US-20100190773-A1 | Anti-Cytokine Heterocyclic Compounds | MAPKAPK2, MAP4K2, MAP3K2 | GRM5 4379/4885GRM3 4506/4885PARP10 1443/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.