Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.42 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.42 |
| ▸ | MTOR | P42345 | 1/20 | 0.41 |
| ▸ | PDK1 | Q15118 | 2/20 | 0.38 |
| ▸ | PDK2 | Q15119 | 2/20 | 0.38 |
| ▸ | PDK3 | Q15120 | 2/20 | 0.38 |
| ▸ | PDK4 | Q16654 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.36 |
| ▸ | SRC | P12931 | 1/20 | 0.36 |
| ▸ | CAMKK1 | Q8N5S9 | 2/20 | 0.36 |
| ▸ | CAMKK2 | Q96RR4 | 2/20 | 0.36 |
| ▸ | PGR | P06401 | 2/20 | 0.36 |
| ▸ | NR3C2 | P08235 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24698959 | 1.00 | MKNK1 (0.42) | MKNK1MKNK2MTORPDK1PDK2 | |
| SCHEMBL24699484 | 0.90 | PDE7A (0.41) | MKNK1MKNK2MTORPDK1PDK2 | |
| SCHEMBL30015689 | 0.90 | PDE7A (0.41) | MKNK1MKNK2MTORPDK1PDK2 | |
| SCHEMBL24698964 | 0.87 | MKNK1 (0.44) | MKNK1MKNK2PDK1PDK2PDK3 | |
| SCHEMBL30015877 | 0.84 | PDK1 (0.40) | MKNK1MKNK2MTORPDK1PDK2 | |
| SCHEMBL30016341 | 0.84 | MTOR (0.44) | MTORPDK1PDK2PDK3PDK4 | |
| SCHEMBL24699474 | 0.84 | MTOR (0.44) | MTORPDK1PDK2PDK3PDK4 | |
| SCHEMBL24699461 | 0.84 | PDK1 (0.40) | MKNK1MKNK2MTORPDK1PDK2 | |
| SCHEMBL24699353 | 0.84 | PDK1 (0.39) | MTORPDK1PDK2PDK3PDK4 | |
| SCHEMBL30015382 | 0.84 | PDK1 (0.39) | MTORPDK1PDK2PDK3PDK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4313967-A1 | KHK INHIBITORS | GILEAD SCIENCES, INC. (US) | 2024-02-07 | — | — | EP | disclosed |
| WO-2022212194-A1 | KHK INHIBITORS | GILEAD SCIENCES, INC. (US) | 2022-10-06 | — | — | WO | disclosed |