Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Neostigmine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 13/20 | 0.97 |
| ▸ | BCHE | P06276 | 7/20 | 0.97 |
| ▸ | LMNA | P02545 | 4/20 | 0.97 |
| ▸ | MEN1 | O00255 | 1/20 | 0.94 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.94 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.94 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
| ▸ | GLA | P06280 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | NCEH1 | Q6PIU2 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Neostigmine SCHEMBL20425365 | 1.00 | ACHE (0.97) | ACHEBCHELMNAMEN1KMT2A | |
| Neostigmine SCHEMBL29603805 | 0.98 | ACHE (1.00) | ACHEBCHELMNAMEN1KMT2A | |
| Neostigmine SCHEMBL34419 | 0.98 | ACHE (1.00) | ACHEBCHELMNAMEN1KMT2A | |
| Neostigmine SCHEMBL8026154 | 0.98 | ACHE (1.00) | ACHEBCHELMNAMEN1KMT2A | |
| Neostigmine SCHEMBL29618009 | 0.97 | ACHE (1.00) | ACHEBCHELMNAMEN1KMT2A | |
| Neostigmine SCHEMBL41128 | 0.97 | ACHE (1.00) | ACHEBCHELMNAMEN1KMT2A | |
| Neostigmine SCHEMBL16228482 | 0.97 | ACHE (0.97) | ACHEBCHELMNAMEN1KMT2A | |
| Neostigmine SCHEMBL7576189 | 0.95 | ACHE (0.94) | ACHEBCHELMNAMEN1KMT2A | |
| Neostigmine SCHEMBL7633009 | 0.92 | ACHE (0.88) | ACHEBCHELMNAMEN1KMT2A | |
| Neostigmine SCHEMBL2028206 | 0.91 | ACHE (0.89) | ACHEBCHELMNAMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119912569-A | Anti-SIRP-beta 1 antibodies and methods of use thereof | 艾利妥 | 2025-05-02 | — | — | CN | claimed |
| CN-118866156-B | Method for predicting microbial corrosion rate of shale gas pipeline | 四川宏大安全技术服务有限公司 | 2025-01-21 | — | — | CN | claimed |
| CN-118866156-A | Method for predicting microbial corrosion rate of shale gas pipeline | 四川宏大安全技术服务有限公司 | 2024-10-29 | — | — | CN | claimed |
| US-20250314324-A1 | CENTERING ELECTRONIC ROTARY VALVE | SCHIVO MEDICAL LIMITED (IE) | 2025-10-09 | — | — | US | disclosed |
| US-20250297693-A1 | CENTERING ELECTRONIC ROTARY VALVE | SCHIVO MEDICAL LIMITED (IE) | 2025-09-25 | — | — | US | disclosed |
| US-12320441-B1 | Centering electronic rotary valve | SCHIVO MEDICAL LIMITED (IE) | 2025-06-03 | — | — | US | disclosed |
| US-12297931-B2 | Centering electronic rotary valve | SCHIVO MEDICAL LIMITED (IE) | 2025-05-13 | — | — | US | disclosed |
| CN-119912569-A | Anti-SIRP-beta 1 antibodies and methods of use thereof | 艾利妥 | 2025-05-02 | — | — | CN | disclosed |
| US-20250026827-A1 | Anti-SIRP-Beta1 Antibodies and Methods of Use Thereof | ALECTOR LLC (US) | 2025-01-23 | — | — | US | disclosed |
| CN-118866156-B | Method for predicting microbial corrosion rate of shale gas pipeline | 四川宏大安全技术服务有限公司 | 2025-01-21 | — | — | CN | disclosed |
| CN-112384532-B | Anti-SIRP-beta 1 antibodies and methods of use thereof | 艾利妥 | 2025-01-10 | — | — | CN | disclosed |
| CN-118866156-A | Method for predicting microbial corrosion rate of shale gas pipeline | 四川宏大安全技术服务有限公司 | 2024-10-29 | — | — | CN | disclosed |
| US-12073883-B2 | Ternary content addressable memory | MACRONIX INTERNATIONAL CO., LTD. (TW) | 2024-08-27 | — | — | US | disclosed |
| US-12060422-B2 | Anti-SIRP-Beta1 antibodies and methods of use thereof | ALECTOR LLC (US) | 2024-08-13 | — | — | US | disclosed |
| CN-117210330-A | Method for screening metabolic ethanol strain by in vitro culture | 中南大学 | 2023-12-12 | — | — | CN | disclosed |
| CN-117095722-A | tri-state content addressable memory | 旺宏电子股份有限公司 | 2023-11-21 | — | — | CN | disclosed |
| US-20230368841-A1 | TERNARY CONTENT ADDRESSABLE MEMORY | MACRONIX INTERNATIONAL CO., LTD. (TW) | 2023-11-16 | — | — | US | disclosed |
| US-20230357610-A1 | PRESSURE-SENSITIVE ADHESIVES AND RELATED METHODS | UNIVERSITY OF WASHINGTON (US) | 2023-11-09 | — | — | US | disclosed |
| EP-3489026-B1 | LITHOGRAPHIC PRINTING PLATE PRECURSOR | FUJIFILM CORP (JP) | 2023-05-24 | — | — | EP | disclosed |
| US-20220341506-A1 | CENTERING ELECTRONIC ROTARY VALVE | SCHIVO MEDICAL LIMITED (IE) | 2022-10-27 | — | — | US | disclosed |