Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KAT6A | Q92794 | 1/20 | 0.44 |
| ▸ | ACACB | O00763 | 2/20 | 0.41 |
| ▸ | CA1 | P00915 | 6/20 | 0.40 |
| ▸ | CA2 | P00918 | 6/20 | 0.40 |
| ▸ | CA12 | O43570 | 5/20 | 0.40 |
| ▸ | CA9 | Q16790 | 5/20 | 0.40 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.40 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.40 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.39 |
| ▸ | NQO2 | P16083 | 1/20 | 0.38 |
| ▸ | NAAA | Q02083 | 1/20 | 0.38 |
| ▸ | ACACA | Q13085 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30029265 | 0.84 | KAT6A (0.41) | KAT6AACACBCA1CA2CA12 | |
| SCHEMBL1725856 | 0.79 | CA1 (0.51) | ACACBCA1CA2CA12CA9 | |
| SCHEMBL2208528 | 0.79 | KAT6A (0.44) | KAT6AACACBSIRT2ADAM17EPHX1 | |
| SCHEMBL4569159 | 0.79 | ACACB (0.44) | KAT6AACACBSIRT2ADAM17EPHX1 | |
| SCHEMBL2205062 | 0.79 | KAT6A (0.47) | KAT6AACACBSIRT2ADAM17EPHX1 | |
| SCHEMBL4569040 | 0.79 | KAT6A (0.47) | KAT6AACACBSIRT2ADAM17EPHX1 | |
| SCHEMBL13379595 | 0.78 | ADAM17 (0.43) | KAT6AACACBSIRT2ADAM17EPHX1 | |
| SCHEMBL30029020 | 0.78 | MTNR1A (0.47) | KAT6AACACBSIRT2ADAM17EPHX1 | |
| SCHEMBL24758236 | 0.77 | KAT6A (0.46) | KAT6ASIRT2 | |
| SCHEMBL2209492 | 0.77 | SIRT2 (0.41) | KAT6AACACBSIRT2ADAM17EPHX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022266394-A1 | NOVEL ISOMEROHYDROLASE INHIBITOR FOR TREATMENT OF ATROPHIC FORM OF AGE-RELATED MACULAR DEGENERATION AND STARGARDT DISEASE | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2022-12-22 | — | — | WO | disclosed |