SCHEMBL2208528

SCHEMBL2208528

CC(CCNC(=O)OC(C)(C)C)c1cccc(OCC2CCCCC2)c1

nearest known ligand 0.61

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
KAT6A Q92794 1/20 0.44
ACACA Q13085 2/20 0.42
ACACB O00763 2/20 0.42
SIRT2 Q8IXJ6 1/20 0.41
ADAM17 P78536 1/20 0.41
GPR88 Q9GZN0 1/20 0.41
DUT P33316 1/20 0.41
PFKFB3 Q16875 1/20 0.40
FAAH O00519 1/20 0.40
PTGS2 P35354 1/20 0.40
EPHX1 P07099 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17735446 0.90 SIRT2 (0.41) KAT6AACACAACACBSIRT2ADAM17
SCHEMBL4569039 0.90 SIRT2 (0.41) KAT6AACACAACACBSIRT2ADAM17
SCHEMBL2209492 0.90 SIRT2 (0.41) KAT6AACACAACACBSIRT2ADAM17
SCHEMBL4569165 0.89 FAAH (0.42) KAT6AACACAACACBSIRT2ADAM17
SCHEMBL2207054 0.89 GPR88 (0.41) KAT6AACACAACACBSIRT2ADAM17
SCHEMBL13324036 0.89 ADAM17 (0.42) KAT6AACACAACACBSIRT2ADAM17
SCHEMBL27996251 0.87 GPR88 (0.46) KAT6AACACAACACBSIRT2ADAM17
SCHEMBL13400275 0.82 ACACB (0.41) ACACBFAAHPTGS2EPHX1
SCHEMBL3386798 0.82 EPHX1 (0.39) ACACBGPR88FAAHPTGS2EPHX1
SCHEMBL25821405 0.81 DUT (0.44) KAT6AACACAACACBSIRT2DUT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 26 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12029708-B2 Alkoxy compounds for disease treatment ACUCELA INC. (US) 2024-07-09 US disclosed
US-20230218549-A1 ALKOXY COMPOUNDS FOR DISEASE TREATMENT ACUCELA INC. 2023-07-13 US disclosed
US-11446261-B2 Alkoxy compounds for disease treatment ACUCELA INC. (US) 2022-09-20 US disclosed
US-20210077427-A1 ALKOXY COMPOUNDS FOR DISEASE TREATMENT ACUCELA INC. 2021-03-18 US disclosed
US-10639286-B2 Alkoxy compounds for disease treatment ACUCELA INC. (US) 2020-05-05 US disclosed
US-20190183816-A1 ALKOXY COMPOUNDS FOR DISEASE TREATMENT ACUCELA INC. 2019-06-20 US disclosed
US-10188615-B2 Alkoxy compounds for disease treatment ACUCELA INC. (US) 2019-01-29 US disclosed
US-20180177746-A1 ALKOXY COMPOUNDS FOR DISEASE TREATMENT ACUCELA INC. 2018-06-28 US disclosed
EP-3210966-A1 ALKOXYPHENYLPROPYLAMINES FOR THE TREATMENT OF AGE-RELATED MACULAR DEGENERATION Acucela, Inc. (US) 2017-08-30 EP disclosed
US-9737496-B2 Alkoxy compounds for disease treatment ACUCELA INC. (US) 2017-08-22 US disclosed
US-8981153-B2 Alkoxy compounds for disease treatment ACUCELA INC. (US) 2015-03-17 US disclosed
US-8829244-B2 Alkoxy compounds for disease treatment ACUCELA INC. (US) 2014-09-09 US disclosed
US-20130197096-A1 ALKOXY COMPOUNDS FOR DISEASE TREATMENT ACUCELA, INC. (US) 2013-08-01 US disclosed
US-20120214852-A1 Alkoxy Compounds for Disease Treatment ACUCELA INC. (US) 2012-08-23 US disclosed
US-20120129894-A1 Alkoxy Compounds for Disease Treatment ACUCELA INC. (US) 2012-05-24 US disclosed
US-20120122938-A1 Alkoxy Compounds for Disease Treatment ACUCELA INC. (US) 2012-05-17 US disclosed
US-7982071-B2 Alkoxy compounds for disease treatment ACUCELA INC. (US) 2011-07-19 US disclosed
US-20090326074-A1 Alkoxy compounds for disease treatment ACUCELA INC. (US) 2009-12-31 US disclosed
EP-2091955-A1 ALKOXY COMPOUNDS FOR DISEASE TREATMENT Acucela, Inc. (US) 2009-08-26 EP disclosed
WO-2009045479-A1 ALKOXY COMPOUNDS FOR DISEASE TREATMENT ACUCELA INC. (US) 2009-04-09 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (13 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12029708-B2 Alkoxy compounds for disease treatment ALDH1A2, CLN6, AGER KAT6A 1820/4885ACACA 229/4885ACACB 139/4885
US-20120122938-A1 Alkoxy Compounds for Disease Treatment ALDH1A2, CLN6, AGER KAT6A 1820/4885ACACA 229/4885ACACB 139/4885
US-20210077427-A1 ALKOXY COMPOUNDS FOR DISEASE TREATMENT ALDH1A2, CLN6, AGER KAT6A 1820/4885ACACA 229/4885ACACB 139/4885
US-20230218549-A1 ALKOXY COMPOUNDS FOR DISEASE TREATMENT ALDH1A2, CLN6, AGER KAT6A 1794/4885ACACA 236/4885ACACB 142/4885
US-20190183816-A1 ALKOXY COMPOUNDS FOR DISEASE TREATMENT ALDH1A2, CLN6, AGER KAT6A 1820/4885ACACA 229/4885ACACB 139/4885
US-20130197096-A1 ALKOXY COMPOUNDS FOR DISEASE TREATMENT ALDH1A2, CLN6, AGER KAT6A 1820/4885ACACA 229/4885ACACB 139/4885
US-11446261-B2 Alkoxy compounds for disease treatment ALDH1A2, CLN6, AGER KAT6A 1820/4885ACACA 229/4885ACACB 139/4885
US-20120214852-A1 Alkoxy Compounds for Disease Treatment ALDH1A2, CLN6, AGER KAT6A 1820/4885ACACA 229/4885ACACB 139/4885
US-20090326074-A1 Alkoxy compounds for disease treatment ALDH1A2, CLN6, AGER KAT6A 1820/4885ACACA 229/4885ACACB 139/4885
US-10188615-B2 Alkoxy compounds for disease treatment ALDH1A2, CLN6, AGER KAT6A 1820/4885ACACA 229/4885ACACB 139/4885
US-20180177746-A1 ALKOXY COMPOUNDS FOR DISEASE TREATMENT ALDH1A2, CLN6, AGER KAT6A 1820/4885ACACA 229/4885ACACB 139/4885
US-20120129894-A1 Alkoxy Compounds for Disease Treatment ALDH1A2, CLN6, AGER KAT6A 1820/4885ACACA 229/4885ACACB 139/4885
US-10639286-B2 Alkoxy compounds for disease treatment ALDH1A2, CLN6, AGER KAT6A 1820/4885ACACA 229/4885ACACB 139/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.