Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYMP | P19971 | 2/20 | 0.41 |
| ▸ | POLA1 | P09884 | 1/20 | 0.41 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.39 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.34 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.34 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | HINT1 | P49773 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3017127 | 0.90 | KDM4E (0.39) | TYMPPOLA1TAS1R3TAS1R1KDM4E | |
| SCHEMBL2113415 | 0.84 | TAS1R3 (0.40) | TYMPPOLA1TAS1R3TAS1R1KDM4E | |
| SCHEMBL16401712 | 0.82 | TYMP (0.55) | TYMPPOLA1TAS1R3TAS1R1KDM4E | |
| SCHEMBL16401149 | 0.81 | TYMP (0.45) | TYMPTAS1R3TAS1R1POLBTAAR1 | |
| SCHEMBL9790905 | 0.80 | ALDH1A1 (0.44) | TYMPPOLA1TAS1R3TAS1R1KDM4E | |
| SCHEMBL9238078 | 0.80 | TYMP (0.58) | TYMPPOLA1TAS1R3TAS1R1KDM4E | |
| SCHEMBL9017501 | 0.79 | TYMP (0.58) | TYMPPOLA1TAS1R3TAS1R1KDM4E | |
| SCHEMBL7534659 | 0.78 | KDM4E (0.49) | TYMPPOLA1TAS1R3TAS1R1KDM4E | |
| SCHEMBL2113125 | 0.78 | KDM4E (0.49) | TYMPPOLA1TAS1R3TAS1R1KDM4E | |
| SCHEMBL9567426 | 0.78 | DUT (0.46) | TYMPPOLA1TAS1R3TAS1R1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8188055-B2 | Inactivators of O6-alkylguanine-DNA alkyltransferase | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2012-05-29 | — | — | US | disclosed |
| US-20100204172-A1 | INACTIVATORS OF O6-ALKYLGUANINE-DNA ALKYLTRANSFERASE | DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2010-08-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100204172-A1 | INACTIVATORS OF O6-ALKYLGUANINE-DNA ALKYLTRANSFERASE | AGT, UNG, DPYD | TYMP 11/4885POLA1 108/4885TAS1R3 4358/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.