Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.36 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.36 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.34 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18372881 | 1.00 | TSHR (0.46) | TSHRNPSR1CYP4F2CYP4A11PIK3C3 | |
| SCHEMBL17241296 | 0.79 | ROCK1 (0.34) | TSHRPIK3C3ROCK2ROCK1NPC1 | |
| SCHEMBL29444538 | 0.78 | TSHR (0.42) | TSHRNPSR1CYP4F2CYP4A11MAPK1 | |
| SCHEMBL30440659 | 0.78 | RET (0.42) | TSHRMAPK1ALDH1A1L3MBTL1ROCK2 | |
| SCHEMBL20210254 | 0.75 | TSHR (0.42) | TSHRNPSR1MAPK1MAPTALDH1A1 | |
| SCHEMBL27486869 | 0.72 | ABL1 (0.36) | TSHRNPSR1CYP4F2CYP4A11MAPK1 | |
| SCHEMBL18420129 | 0.71 | TSHR (0.37) | TSHRNPSR1CYP4F2CYP4A11MAPT | |
| SCHEMBL23500618 | 0.71 | ALOX15 (0.48) | CYP4F2CYP4A11ALDH1A1KDM4EL3MBTL1 | |
| SCHEMBL24339322 | 0.71 | MAPK1 (0.47) | TSHRNPSR1MAPK1MAPTALDH1A1 | |
| SCHEMBL30119558 | 0.71 | ALDH1A1 (0.46) | NPSR1MAPTALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112074519-B | Compounds useful as inhibitors of RIP1 kinase for the treatment of, for example, irritable Bowel Syndrome (IBS) | 豪夫迈·罗氏有限公司 | 2024-08-02 | — | — | CN | disclosed |
| EP-3781571-B1 | N-[4-OXO-2,3-DIHYDRO-PYRIDO[3,2-B][1,4]OXAZEPIN-3-YL]-5,6-DIHYDRO-4H-PYRROLO[1,2-B]PYRAZOLE-2-CARBOXAMIDE DERIVATIVES AND RELATED COMPOUNDS AS RIP1 KINASE INHIBITORS FOR TREATING E.G. IRRITABLE BOWEL SYNDROME (IBS) | HOFFMANN LA ROCHE (CH) | 2024-01-17 | — | — | EP | disclosed |
| US-11634436-B2 | Pyridine lactam compounds and methods of use thereof | GENENTECH, INC. (US) | 2023-04-25 | — | — | US | disclosed |
| CN-110072863-B | RIP1 kinase inhibitors and methods of use | 豪夫迈·罗氏有限公司 | 2022-08-30 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11634436-B2 | Pyridine lactam compounds and methods of use thereof | RB1, RBX1, RPSA | TSHR 2704/4885NPSR1 2125/4885CYP4F2 1266/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.